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Microorganisms 2017, 5(1), 13; doi:10.3390/microorganisms5010013

Immune Response to Coccidioidomycosis and the Development of a Vaccine

1
Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249, USA
2
Immune Defense Core, University of Texas, San Antonio, TX 78249, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Miguel Viñas
Received: 10 September 2016 / Revised: 3 March 2017 / Accepted: 14 March 2017 / Published: 16 March 2017
(This article belongs to the Special Issue Fungal Pathogenesis and Immune Defense)
View Full-Text   |   Download PDF [775 KB, uploaded 16 March 2017]   |  

Abstract

Coccidioidomycosis is a fungal infection caused by Coccidioides posadasii and Coccidioides immitis. It is estimated that 150,000 new infections occur in the United States each year. The incidence of this infection continues to rise in endemic regions. There is an urgent need for the development of better therapeutic drugs and a vaccine against coccidioidomycosis. This review discusses the features of host innate and adaptive immune responses to Coccidioides infection. The focus is on the recent advances in the immune response and host-pathogen interactions, including the recognition of spherules by the host and defining the signal pathways that guide the development of the adaptive T-cell response to Coccidioides infection. Also discussed is an update on progress in developing a vaccine against these fungal pathogens. View Full-Text
Keywords: Coccidioides; San Joaquin Valley fever; coccidioidomycosis; fungal infection; innate immunity; Coccidioides vaccine; T-cell response Coccidioides; San Joaquin Valley fever; coccidioidomycosis; fungal infection; innate immunity; Coccidioides vaccine; T-cell response
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Castro-Lopez, N.; Hung, C.-Y. Immune Response to Coccidioidomycosis and the Development of a Vaccine. Microorganisms 2017, 5, 13.

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