Immunoregulation in Fungal Diseases
AbstractThis review addresses specific regulatory mechanisms involved in the host immune response to fungal organisms. We focus on key cells and regulatory pathways involved in these responses, including a brief overview of their broader function preceding a discussion of their specific relevance to fungal disease. Important cell types discussed include dendritic cells and regulatory T cells, with a focus on specific studies relating to their effects on immune responses to fungi. We highlight the interleukin-10, programmed cell death 1, and cytotoxic T lymphocyte-associated protein 4 signaling pathways and emphasize interrelationships between these pathways and the regulatory functions of dendritic cells and regulatory T cells. Throughout our discussion, we identify selected studies best illustrating the role of these cells and pathways in response to specific fungal pathogens to provide a contextual understanding of the tightly-controlled network of regulatory mechanisms critical to determining the outcome of exposure to fungal pathogens. Lastly, we discuss two unique phenomena relating to immunoregulation, protective tolerance and immune reactivation inflammatory syndrome. These two clinically-relevant conditions provide perspective as to the range of immunoregulatory mechanisms active in response to fungi. View Full-Text
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Roussey, J.A.; Olszewski, M.A.; Osterholzer, J.J. Immunoregulation in Fungal Diseases. Microorganisms 2016, 4, 47.
Roussey JA, Olszewski MA, Osterholzer JJ. Immunoregulation in Fungal Diseases. Microorganisms. 2016; 4(4):47.Chicago/Turabian Style
Roussey, Jonathan A.; Olszewski, Michal A.; Osterholzer, John J. 2016. "Immunoregulation in Fungal Diseases." Microorganisms 4, no. 4: 47.
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