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Whole Genome Classification and Phylogenetic Analyses of Rotavirus B strains from the United States
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Pathogens 2018, 7(2), 46; https://doi.org/10.3390/pathogens7020046

Genome Characterization of a Pathogenic Porcine Rotavirus B Strain Identified in Buryat Republic, Russia in 2015

1
N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Gamaleya Str. 18, Moscow 123098, Russia
2
Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, Moscow 109428, Russia
3
A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia
4
Institute for Information Transmission Problems of the Russian Academy of Sciences, Moscow 127051, Russia
5
Laboratory of Extreme Biology, Institute of Fundamental Biology and Medicine, Kazan Federal University, Kazan 420021, Russia
6
Department of Genetics, Faculty of Biology, Lomonosov Moscow State University, Moscow 119991, Russia
7
Independent Non-Profit Organization “Diagnostic and Prevention Research Institute for Human and Animal Diseases”, Moscow 123098, Russia
8
The Ministry of Agriculture of the Russian Federation, Orlikov Pereulok 1/11, Moscow 107139, Russia
9
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66502, USA
10
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA
These authors equally contributed to the study.
*
Authors to whom correspondence should be addressed.
Received: 5 March 2018 / Revised: 13 April 2018 / Accepted: 13 April 2018 / Published: 20 April 2018
(This article belongs to the Special Issue Rotavirus Epidemiology: Host, Climate and Vaccine Influences)
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Abstract

An outbreak of enteric disease of unknown etiology with 60% morbidity and 8% mortality in weaning piglets occurred in November 2015 on a farm in Buryat Republic, Russia. Metagenomic sequencing revealed the presence of rotavirus B in feces from diseased piglets while no other pathogens were identified. Clinical disease was reproduced in experimentally infected piglets, yielding the 11 RVB gene segments for strain Buryat15, with an RVB genotype constellation of G12-P[4]-I13-R4-C4-M4-A8-N10-T4-E4-H7. This genotype constellation has also been identified in the United States. While the Buryat15 VP7 protein lacked unique amino acid differences in the predicted neutralizing epitopes compared to the previously published swine RVB G12 strains, this report of RVB in Russian swine increases our epidemiological knowledge on the global prevalence and genetic diversity of RVB. View Full-Text
Keywords: porcine group B rotavirus; RVB; gastrointestinal disease; porcine enteric disease; phylogenetic analysis porcine group B rotavirus; RVB; gastrointestinal disease; porcine enteric disease; phylogenetic analysis
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Alekseev, K.P.; Penin, A.A.; Mukhin, A.N.; Khametova, K.M.; Grebennikova, T.V.; Yuzhakov, A.G.; Moskvina, A.S.; Musienko, M.I.; Raev, S.A.; Mishin, A.M.; Kotelnikov, A.P.; Verkhovsky, O.A.; Aliper, T.I.; Nepoklonov, E.A.; Herrera-Ibata, D.M.; Shepherd, F.K.; Marthaler, D.G. Genome Characterization of a Pathogenic Porcine Rotavirus B Strain Identified in Buryat Republic, Russia in 2015. Pathogens 2018, 7, 46.

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