Genome Characterization of a Pathogenic Porcine Rotavirus B Strain Identified in Buryat Republic, Russia in 2015
AbstractAn outbreak of enteric disease of unknown etiology with 60% morbidity and 8% mortality in weaning piglets occurred in November 2015 on a farm in Buryat Republic, Russia. Metagenomic sequencing revealed the presence of rotavirus B in feces from diseased piglets while no other pathogens were identified. Clinical disease was reproduced in experimentally infected piglets, yielding the 11 RVB gene segments for strain Buryat15, with an RVB genotype constellation of G12-P-I13-R4-C4-M4-A8-N10-T4-E4-H7. This genotype constellation has also been identified in the United States. While the Buryat15 VP7 protein lacked unique amino acid differences in the predicted neutralizing epitopes compared to the previously published swine RVB G12 strains, this report of RVB in Russian swine increases our epidemiological knowledge on the global prevalence and genetic diversity of RVB. View Full-Text
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Alekseev, K.P.; Penin, A.A.; Mukhin, A.N.; Khametova, K.M.; Grebennikova, T.V.; Yuzhakov, A.G.; Moskvina, A.S.; Musienko, M.I.; Raev, S.A.; Mishin, A.M.; Kotelnikov, A.P.; Verkhovsky, O.A.; Aliper, T.I.; Nepoklonov, E.A.; Herrera-Ibata, D.M.; Shepherd, F.K.; Marthaler, D.G. Genome Characterization of a Pathogenic Porcine Rotavirus B Strain Identified in Buryat Republic, Russia in 2015. Pathogens 2018, 7, 46.
Alekseev KP, Penin AA, Mukhin AN, Khametova KM, Grebennikova TV, Yuzhakov AG, Moskvina AS, Musienko MI, Raev SA, Mishin AM, Kotelnikov AP, Verkhovsky OA, Aliper TI, Nepoklonov EA, Herrera-Ibata DM, Shepherd FK, Marthaler DG. Genome Characterization of a Pathogenic Porcine Rotavirus B Strain Identified in Buryat Republic, Russia in 2015. Pathogens. 2018; 7(2):46.Chicago/Turabian Style
Alekseev, Konstantin P.; Penin, Aleksey A.; Mukhin, Alexey N.; Khametova, Kizkhalum M.; Grebennikova, Tatyana V.; Yuzhakov, Anton G.; Moskvina, Anna S.; Musienko, Maria I.; Raev, Sergey A.; Mishin, Alexandr M.; Kotelnikov, Alexandr P.; Verkhovsky, Oleg A.; Aliper, Taras I.; Nepoklonov, Eugeny A.; Herrera-Ibata, Diana M.; Shepherd, Frances K.; Marthaler, Douglas G. 2018. "Genome Characterization of a Pathogenic Porcine Rotavirus B Strain Identified in Buryat Republic, Russia in 2015." Pathogens 7, no. 2: 46.
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