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Pathogens 2017, 6(1), 10; doi:10.3390/pathogens6010010

Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis

College of Veterinary Medicine, Department of Infectious Diseases, The University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, USA
Academic Editor: Sandip K. Datta
Received: 23 December 2016 / Accepted: 3 March 2017 / Published: 9 March 2017
(This article belongs to the Special Issue Host Defense Against Bacteria)
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Abstract

Cystic fibrosis (CF) affects 70,000 patients worldwide. Morbidity and mortality in CF is largely caused by lung complications due to the triad of impaired mucociliary clearance, microbial infections and chronic inflammation. Cystic fibrosis airway inflammation is mediated by robust infiltration of polymorphonuclear neutrophil granulocytes (PMNs, neutrophils). Neutrophils are not capable of clearing lung infections and contribute to tissue damage by releasing their dangerous cargo. Pseudomonas aeruginosa is an opportunistic pathogen causing infections in immunocompromised individuals. P. aeruginosa is a main respiratory pathogen in CF infecting most patients. Although PMNs are key to attack and clear P. aeruginosa in immunocompetent individuals, PMNs fail to do so in CF. Understanding why neutrophils cannot clear P. aeruginosa in CF is essential to design novel therapies. This review provides an overview of the antimicrobial mechanisms by which PMNs attack and eliminate P. aeruginosa. It also summarizes current advances in our understanding of why PMNs are incapable of clearing P. aeruginosa and how this bacterium adapts to and resists PMN-mediated killing in the airways of CF patients chronically infected with P. aeruginosa. View Full-Text
Keywords: Pseudomonas aeruginosa; cystic fibrosis; neutrophil; neutrophil extracellular traps; biofilm; flagellum; phagocytosis; oxidative; killing Pseudomonas aeruginosa; cystic fibrosis; neutrophil; neutrophil extracellular traps; biofilm; flagellum; phagocytosis; oxidative; killing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rada, B. Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis. Pathogens 2017, 6, 10.

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