Adhesive Pili in UTI Pathogenesis and Drug Development
AbstractUrinary tract infections (UTIs) are one of the most common bacterial infections, affecting 150 million people each year worldwide. High recurrence rates and increasing antimicrobial resistance among uropathogens are making it imperative to develop alternative strategies for the treatment and prevention of this common infection. In this Review, we discuss how understanding the: (i) molecular and biophysical basis of host-pathogen interactions; (ii) consequences of the molecular cross-talk at the host pathogen interface in terms of disease progression; and (iii) pathophysiology of UTIs is leading to efforts to translate this knowledge into novel therapeutics to treat and prevent these infections. View Full-Text
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Spaulding, C.N.; Hultgren, S.J. Adhesive Pili in UTI Pathogenesis and Drug Development. Pathogens 2016, 5, 30.
Spaulding CN, Hultgren SJ. Adhesive Pili in UTI Pathogenesis and Drug Development. Pathogens. 2016; 5(1):30.Chicago/Turabian Style
Spaulding, Caitlin N.; Hultgren, Scott J. 2016. "Adhesive Pili in UTI Pathogenesis and Drug Development." Pathogens 5, no. 1: 30.
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