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Pathogens 2016, 5(1), 30; doi:10.3390/pathogens5010030

Adhesive Pili in UTI Pathogenesis and Drug Development

1
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
2
Center for Women’s Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Received: 16 July 2015 / Revised: 15 February 2016 / Accepted: 7 March 2016 / Published: 15 March 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
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Abstract

Urinary tract infections (UTIs) are one of the most common bacterial infections, affecting 150 million people each year worldwide. High recurrence rates and increasing antimicrobial resistance among uropathogens are making it imperative to develop alternative strategies for the treatment and prevention of this common infection. In this Review, we discuss how understanding the: (i) molecular and biophysical basis of host-pathogen interactions; (ii) consequences of the molecular cross-talk at the host pathogen interface in terms of disease progression; and (iii) pathophysiology of UTIs is leading to efforts to translate this knowledge into novel therapeutics to treat and prevent these infections. View Full-Text
Keywords: UTI; rUTI; CAUTI; pili; UPEC; chaperone-usher pathway (CUP) pili; Enterococcus; vaccine; antibiotic-resistance UTI; rUTI; CAUTI; pili; UPEC; chaperone-usher pathway (CUP) pili; Enterococcus; vaccine; antibiotic-resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Spaulding, C.N.; Hultgren, S.J. Adhesive Pili in UTI Pathogenesis and Drug Development. Pathogens 2016, 5, 30.

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