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Pathogens 2016, 5(1), 25; doi:10.3390/pathogens5010025

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli

1
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, München 81675, Germany
2
Institute of Human Virology, Departments of Medicine, and Microbiology and Immunology, University of Maryland, School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA
3
Department of Pathology, Case Western Reserve University, 2103 Cornell Rd, Cleveland, OH 44106, USA
4
Department of Microbiology, Immunology and Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, 221 00 Lund, Sweden
5
Institute of Medical Microbiology and Hygiene, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Received: 11 September 2015 / Revised: 23 February 2016 / Accepted: 25 February 2016 / Published: 29 February 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
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Abstract

The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters. View Full-Text
Keywords: bacterial pathogens; Toll-like receptors; TIR-containing proteins; TIR-domain structure bacterial pathogens; Toll-like receptors; TIR-containing proteins; TIR-domain structure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Waldhuber, A.; Snyder, G.A.; Römmler, F.; Cirl, C.; Müller, T.; Xiao, T.S.; Svanborg, C.; Miethke, T. A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli. Pathogens 2016, 5, 25.

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