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Pathogens 2016, 5(1), 23; doi:10.3390/pathogens5010023

Perspective: Adhesion Mediated Signal Transduction in Bacterial Pathogens

1
Biology Department, Rutgers University-Camden, 200 Federal St., Suite 520, Camden, NJ 08103, USA
2
Center for Computational and Integrative Biology, Rutgers University-Camden, 200 Federal St., Suite 520, Camden, NJ 08103, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Catharina Svanborg
Received: 16 July 2015 / Revised: 28 January 2016 / Accepted: 13 February 2016 / Published: 18 February 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
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Abstract

During the infection process, pathogenic bacteria undergo large-scale transcriptional changes to promote virulence and increase intrahost survival. While much of this reprogramming occurs in response to changes in chemical environment, such as nutrient availability and pH, there is increasing evidence that adhesion to host-tissue can also trigger signal transduction pathways resulting in differential gene expression. Determining the molecular mechanisms of adhesion-mediated signaling requires disentangling the contributions of chemical and mechanical stimuli. Here we highlight recent work demonstrating that surface attachment drives a transcriptional response in bacterial pathogens, including uropathogenic Escherichia coli (E. coli), and discuss the complexity of experimental design when dissecting the specific role of adhesion-mediated signaling during infection. View Full-Text
Keywords: adhesion; signal transduction; virulence; uropathogenic E. coli; fimbriae adhesion; signal transduction; virulence; uropathogenic E. coli; fimbriae
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moorthy, S.; Keklak, J.; Klein, E.A. Perspective: Adhesion Mediated Signal Transduction in Bacterial Pathogens. Pathogens 2016, 5, 23.

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