Pathogens 2016, 5(1), 14; doi:10.3390/pathogens5010014
Genetic Variations in Vesicoureteral Reflux Sequelae
1
Innate Immunity Translational Research Center, Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN 38103, USA
2
Department of Pediatrics, Nationwide Children’s Hospital, Columbus, OH 43205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Catharina Svanborg
Received: 11 September 2015 / Revised: 20 January 2016 / Accepted: 21 January 2016 / Published: 2 February 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
Abstract
Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview, we discuss how current cohorts and genetic strategies can be implemented to discover new susceptibility loci in patients with UTI. View Full-Text
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Hains, D.S.; Schwaderer, A.L. Genetic Variations in Vesicoureteral Reflux Sequelae. Pathogens 2016, 5, 14.
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