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Pathogens 2016, 5(1), 13; doi:10.3390/pathogens5010013

Novel Strategies in the Prevention and Treatment of Urinary Tract Infections

Department of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, Stockholm SE-171 76, Sweden
Current affiliation: Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, Stockholm SE-141 86, Sweden
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Author to whom correspondence should be addressed.
Academic Editor: Catharina Svanborg
Received: 16 July 2015 / Revised: 5 August 2015 / Accepted: 21 January 2016 / Published: 27 January 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
View Full-Text   |   Download PDF [226 KB, uploaded 27 January 2016]

Abstract

Urinary tract infections are one of the most common bacterial infections, especially in women and children, frequently treated with antibiotics. The alarming increase in antibiotic resistance is a global threat to future treatment of infections. Therefore, alternative strategies are urgently needed. The innate immune system plays a fundamental role in protecting the urinary tract from infections. Antimicrobial peptides form an important part of the innate immunity. They are produced by epithelial cells and neutrophils and defend the urinary tract against invading bacteria. Since efficient resistance mechanisms have not evolved among bacterial pathogens, much effort has been put into exploring the role of antimicrobial peptides and possibilities to utilize them in clinical practice. Here, we describe the impact of antimicrobial peptides in the urinary tract and ways to enhance the production by hormones like vitamin D and estrogen. We also discuss the potential of medicinal herbs to be used in the prophylaxis and the treatment of urinary tract infections. View Full-Text
Keywords: urinary tract infection; antimicrobial peptides; estrogen; vitamin D; herbal extracts urinary tract infection; antimicrobial peptides; estrogen; vitamin D; herbal extracts
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lüthje, P.; Brauner, A. Novel Strategies in the Prevention and Treatment of Urinary Tract Infections. Pathogens 2016, 5, 13.

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