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Pathogens 2015, 4(4), 883-893; doi:10.3390/pathogens4040883

Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?

1
Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
2
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ying-Lien Chen
Received: 23 November 2015 / Revised: 7 December 2015 / Accepted: 11 December 2015 / Published: 16 December 2015
(This article belongs to the Special Issue Human Fungal Pathogens)
View Full-Text   |   Download PDF [339 KB, uploaded 16 December 2015]   |  

Abstract

Studies on fungal pathogens belonging to the ascomycota phylum are critical given the ubiquity and frequency with which these fungi cause infections in humans. Among these species, Aspergillus fumigatus causes invasive aspergillosis, a leading cause of death in immunocompromised patients. Fundamental to A. fumigatus pathogenesis is hyphal growth. However, the precise mechanisms underlying hyphal growth and virulence are poorly understood. Over the past 10 years, our research towards the identification of molecular targets responsible for hyphal growth, drug resistance and virulence led to the elucidation of calcineurin as a key signaling molecule governing these processes. In this review, we summarize our salient findings on the significance of calcineurin for hyphal growth and septation in A. fumigatus and propose future perspectives on exploiting this pathway for designing new fungal-specific therapeutics. View Full-Text
Keywords: Aspergillus fumigatus; calcineurin; hyphal growth; septation; virulence; FK506; cyclosporine A; phosphorylation; drug target; drug resistance Aspergillus fumigatus; calcineurin; hyphal growth; septation; virulence; FK506; cyclosporine A; phosphorylation; drug target; drug resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Juvvadi, P.R.; Steinbach, W.J. Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here? Pathogens 2015, 4, 883-893.

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