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Pathogens 2015, 4(4), 869-882; doi:10.3390/pathogens4040869

Coordinated Molecular Cross-Talk between Staphylococcus aureus, Endothelial Cells and Platelets in Bloodstream Infection

Cardiovascular Infection Research Group, School of Pharmacy & Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland
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Academic Editors: Rachel McLoughlin and Lawrence S. Young
Received: 15 October 2015 / Accepted: 2 December 2015 / Published: 5 December 2015
(This article belongs to the Special Issue Staphylococcus Aureus Infection)
View Full-Text   |   Download PDF [211 KB, uploaded 5 December 2015]

Abstract

Staphylococcus aureus is an opportunistic pathogen often carried asymptomatically on the human body. Upon entry to the otherwise sterile environment of the cardiovascular system, S. aureus can lead to serious complications resulting in organ failure and death. The success of S. aureus as a pathogen in the bloodstream is due to its ability to express a wide array of cell wall proteins on its surface that recognise host receptors, extracellular matrix proteins and plasma proteins. Endothelial cells and platelets are important cells in the cardiovascular system and are a major target of bloodstream infection. Endothelial cells form the inner lining of a blood vessel and provide an antithrombotic barrier between the vessel wall and blood. Platelets on the other hand travel throughout the cardiovascular system and respond by aggregating around the site of injury and initiating clot formation. Activation of either of these cells leads to functional dysregulation in the cardiovascular system. In this review, we will illustrate how S. aureus establish intimate interactions with both endothelial cells and platelets leading to cardiovascular dysregulation. View Full-Text
Keywords: Staphylococcus aureus; platelets; endothelial cells; sepsis; infective endocarditis Staphylococcus aureus; platelets; endothelial cells; sepsis; infective endocarditis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Garciarena, C.D.; McHale, T.M.; Watkin, R.L.; Kerrigan, S.W. Coordinated Molecular Cross-Talk between Staphylococcus aureus, Endothelial Cells and Platelets in Bloodstream Infection. Pathogens 2015, 4, 869-882.

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