Pathogens 2015, 4(3), 422-430; doi:10.3390/pathogens4030422
Molecular Characterization of the Multidrug Resistant Escherichia coli ST131 Clone
1
School of Chemistry & Molecular Biosciences, the University of Queensland, Brisbane, Queensland 4072, Australia
2
Australian Infectious Diseases Research Centre, the University of Queensland, Brisbane, Queensland 4072, Australia
*
Authors to whom correspondence should be addressed.
Academic Editor: Lawrence Young
Received: 25 May 2015 / Revised: 8 June 2015 / Accepted: 23 June 2015 / Published: 26 June 2015
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
Abstract
Escherichia coli ST131 is a recently emerged and globally disseminated multidrug resistant clone associated with urinary tract and bloodstream infections in both community and clinical settings. The most common group of ST131 strains are defined by resistance to fluoroquinolones and possession of the type 1 fimbriae fimH30 allele. Here we provide an update on our recent work describing the globally epidemiology of ST131. We review the phylogeny of ST131 based on whole genome sequence data and highlight the important role of recombination in the evolution of this clonal lineage. We also summarize our findings on the virulence of the ST131 reference strain EC958, and highlight the use of transposon directed insertion-site sequencing to define genes associated with serum resistance and essential features of its large antibiotic resistance plasmid pEC958. View Full-TextKeywords:
uropathogenic Escherichia coli; ST131; urinary tract; FimH; virulence; genomics; TraDIS; plasmid; antibiotic resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Schembri, M.A.; Zakour, N.L.B.; Phan, M.-D.; Forde, B.M.; Stanton-Cook, M.; Beatson, S.A. Molecular Characterization of the Multidrug Resistant Escherichia coli ST131 Clone. Pathogens 2015, 4, 422-430.
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