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Pathogens 2014, 3(3), 563-576; https://doi.org/10.3390/pathogens3030563

Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Current Address: California Institute for Biomedical Research (Calibr), La Jolla, CA 92037, USA.
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Received: 15 April 2014 / Revised: 23 June 2014 / Accepted: 23 June 2014 / Published: 3 July 2014
(This article belongs to the Special Issue Animal Model to Study Viral Immunity)
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Abstract

CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therapeutic target for anti-HBV treatment. We aim to humanize mice in the CD1d/iNKT cell lipid presentation system and provide new research tools for identifying novel anti-HBV agents. View Full-Text
Keywords: HBV; NKT; humanized mice; antivirals; immunotherapy HBV; NKT; humanized mice; antivirals; immunotherapy
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Lawrenczyk, A.; Kim, S.; Wen, X.; Xiong, R.; Yuan, W. Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment. Pathogens 2014, 3, 563-576.

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