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Pathogens 2014, 3(1), 187-210; doi:10.3390/pathogens3010187
Review

Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota

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Received: 21 December 2013; in revised form: 6 February 2014 / Accepted: 18 February 2014 / Published: 28 February 2014
(This article belongs to the Special Issue Gut Microbiome)
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Abstract: Trillions of microorganisms that inhabit the intestinal tract form a diverse and intricate ecosystem with a deeply embedded symbiotic relationship with their hosts. As more detailed information on gut microbiota complexity and functional diversity accumulates, we are learning more about how diet-microbiota interactions can influence the immune system within and outside the gut and host health in general. Heat shock proteins are a set of highly conserved proteins that are present in all types of cells, from microbes to mammals. These proteins carry out crucial intracellular housekeeping functions and unexpected extracellular immuno-regulatory features in order to maintain the mucosal barrier integrity and gut homeostasis. It is becoming evident that the enteric microbiota is one of the major determinants of heat shock protein production in intestinal epithelial cells. This review will focus on the interactions between diet, gut microbiota and their role for regulating heat shock protein production and, furthermore, how these interactions influence the immune system and the integrity of the mucosal barrier.
Keywords: heat shock protein; gut homeostasis; microbiota; tight junction protein; Lactobacillus spp.; butyrate-producing bacteria; dietary fiber heat shock protein; gut homeostasis; microbiota; tight junction protein; Lactobacillus spp.; butyrate-producing bacteria; dietary fiber
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, H.; Dicksved, J.; Lundh, T.; Lindberg, J.E. Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota. Pathogens 2014, 3, 187-210.

AMA Style

Liu H, Dicksved J, Lundh T, Lindberg JE. Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota. Pathogens. 2014; 3(1):187-210.

Chicago/Turabian Style

Liu, Haoyu; Dicksved, Johan; Lundh, Torbjörn; Lindberg, Jan E. 2014. "Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota." Pathogens 3, no. 1: 187-210.


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