Next Article in Journal
From Exit to Entry: Long-term Survival and Transmission of Salmonella
Next Article in Special Issue
Epstein-Barr Virus Sequence Variation—Biology and Disease
Previous Article in Journal / Special Issue
Hypomethylation and Over-Expression of the Beta Isoform of BLIMP1 is Induced by Epstein-Barr Virus Infection of B Cells; Potential Implications for the Pathogenesis of EBV-Associated Lymphomas
Pathogens 2012, 1(2), 102-127; doi:10.3390/pathogens1020102
Review

Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus

 and *
Received: 2 September 2012; in revised form: 11 October 2012 / Accepted: 13 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Infection and Cancer)
View Full-Text   |   Download PDF [317 KB, uploaded 22 October 2012]
Abstract: As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other lymphoproliferative malignancies. KSHV entry into cells is tightly regulated by diverse viral and cellular factors. In particular, KSHV actively engages cellular integrins and ubiquitination pathways for successful infection. Emerging evidence suggests that KSHV hijacks both actin and microtubule cytoskeletons at different phases during entry into cells. Here, we review recent findings on the early events during primary infection of KSHV and its closely related primate homolog rhesus rhadinovirus with highlights on the regulation of cellular cytoskeletons and signaling pathways that are important for this phase of virus life cycle.
Keywords: Kaposi’s Sarcoma-Associated Herpesvirus (KSHV); Rhesus Rhadinovirus (RRV); virus entry; endocytosis; actin; microtubule; integrin; cellular signaling; ubiquitination Kaposi’s Sarcoma-Associated Herpesvirus (KSHV); Rhesus Rhadinovirus (RRV); virus entry; endocytosis; actin; microtubule; integrin; cellular signaling; ubiquitination
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Zhang, W.; Gao, S.-J. Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens 2012, 1, 102-127.

AMA Style

Zhang W, Gao S-J. Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens. 2012; 1(2):102-127.

Chicago/Turabian Style

Zhang, Wei; Gao, Shou-Jiang. 2012. "Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus." Pathogens 1, no. 2: 102-127.


Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert