Pathogens 2012, 1(1), 52-64; doi:10.3390/pathogens1010052
Article

Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin’s Lymphoma

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Received: 14 August 2012; in revised form: 28 August 2012 / Accepted: 4 September 2012 / Published: 19 September 2012
(This article belongs to the Special Issue Infection and Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Although there is increasing evidence that aberrant expression of those enzymes which control protein arginine methylation contribute to carcinogenesis, their de-regulation by oncogenic viruses in primary cells has yet to be reported. We first show that the protein arginine methyltransferases, CARM1, PRMT1 and PRMT5 are strongly expressed in Hodgkin Reed-Sternberg (HRS) cells, and up-regulated in Hodgkin's lymphoma (HL) cell lines. Given that Epstein-Barr virus (EBV) can be detected in approximately 50% of primary HL, we next examined how EBV infection of germinal centre (GC) B cells, the presumptive precursors of HRS cells, modulated the expression of these proteins. EBV infection of GC B cells was followed by the up-regulation of CARM1, PRMT1 and PRMT5, and by the down-regulation of the arginine deiminase, PADI4. Latent membrane protein 1 (LMP1), the major EBV transforming gene was shown to induce PRMT1 in GC B cells and in a stably transfected B cell line. The recent development of compounds which inhibit PRMT-mediated reactions provides a compelling case for continuing to dissect the contribution of virus induced changes in these proteins to lymphomagenesis.
Keywords: protein arginine methyltransferases; Epstein-Barr virus; LMP1; Hodgkin’s lymphoma; PRMT1; epigenetics
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MDPI and ACS Style

Leonard, S.; Gordon, N.; Smith, N.; Rowe, M.; Murray, P.G.; Woodman, C.B. Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin’s Lymphoma. Pathogens 2012, 1, 52-64.

AMA Style

Leonard S, Gordon N, Smith N, Rowe M, Murray PG, Woodman CB. Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin’s Lymphoma. Pathogens. 2012; 1(1):52-64.

Chicago/Turabian Style

Leonard, Sarah; Gordon, Naheema; Smith, Nikki; Rowe, Martin; Murray, Paul G.; Woodman, Ciarán B. 2012. "Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin’s Lymphoma." Pathogens 1, no. 1: 52-64.

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