Next Article in Journal
Microstructure and Microhardness of Laser Metal Deposition Shaping K465/Stellite-6 Laminated Material
Next Article in Special Issue
The Suitability of Zn–1.3%Fe Alloy as a Biodegradable Implant Material
Previous Article in Journal
Wear of Shaped Surfaces of PVD Coated Dies for Clinching
Previous Article in Special Issue
Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessFeature PaperReview
Metals 2017, 7(11), 514; doi:10.3390/met7110514

The Biological Responses to Magnesium-Based Biodegradable Medical Devices

National Science Foundation-Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC 27401, USA
FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, NC 27401, USA
Department of Anesthesiology, School of Medicine, Yale University, New Haven, CT 06519, USA
Author to whom correspondence should be addressed.
Received: 20 September 2017 / Revised: 16 November 2017 / Accepted: 18 November 2017 / Published: 21 November 2017
(This article belongs to the Special Issue Biodegradable Metals)
View Full-Text   |   Download PDF [898 KB, uploaded 22 November 2017]   |  


The biocompatibility of Magnesium-based materials (MBMs) is critical to the safety of biodegradable medical devices. As a promising metallic biomaterial for medical devices, the issue of greatest concern is devices’ safety as degrading products are possibly interacting with local tissue during complete degradation. The aim of this review is to summarize the biological responses to MBMs at the cellular/molecular level, including cell adhesion, transportation signaling, immune response, and tissue growth during the complex degradation process. We review the influence of MBMs on gene/protein biosynthesis and expression at the site of implantation, as well as throughout the body. This paper provides a systematic review of the cellular/molecular behavior of local tissue on the response to Mg degradation, which may facilitate a better prediction of long-term degradation and the safe use of magnesium-based implants through metal innovation. View Full-Text
Keywords: biological responses; biocompatibility; biodegradable; magnesium-based materials biological responses; biocompatibility; biodegradable; magnesium-based materials

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, L.; Wang, J.; Russell, T.; Sankar, J.; Yun, Y. The Biological Responses to Magnesium-Based Biodegradable Medical Devices. Metals 2017, 7, 514.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Metals EISSN 2075-4701 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top