Antimicrobial Nanostructured Bioactive Coating Based on Fe3O4 and Patchouli Oil for Wound Dressing
AbstractThe aim of this study was to develop a biocompatible coating for wound dressings, containing iron oxide nanoparticles functionalized with patchouli essential oil in order to obtain improved antimicrobial properties able to prevent biofilm development and consecutive associated infections. The bioactive coating was prepared by the co-precipitation of a precursor in an alkaline solution of patchouli oil. The prepared surface was characterized by XRD (X ray diffraction), TEM (transmission electron microscopy), SAED (selected area diffraction), SEM (scanning electron microscopy) and FT-IR (Fourier transform infrared spectroscopy). The bioevaluation of the obtained coating consisted in antimicrobial, as well as in vitro and in vivo biocompatibility and biodistribution assays. The obtained coating revealed a strong anti-biofilm activity maintained up to 72 h, as well as a low cytotoxicity on mammalian cells and a good biodistribution after intraperitoneal injection in mice. These results demonstrate the promising potential of the respective coatings for the management of wound infections and for the development of soft materials with improved resistance to microbial colonization. View Full-Text
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Rădulescu, M.; Andronescu, E.; Holban, A.M.; Vasile, B.S.; Iordache, F.; Mogoantă, L.; Mogoșanu, G.D.; Grumezescu, A.M.; Georgescu, M.; Chifiriuc, M.C. Antimicrobial Nanostructured Bioactive Coating Based on Fe3O4 and Patchouli Oil for Wound Dressing. Metals 2016, 6, 103.
Rădulescu M, Andronescu E, Holban AM, Vasile BS, Iordache F, Mogoantă L, Mogoșanu GD, Grumezescu AM, Georgescu M, Chifiriuc MC. Antimicrobial Nanostructured Bioactive Coating Based on Fe3O4 and Patchouli Oil for Wound Dressing. Metals. 2016; 6(5):103.Chicago/Turabian Style
Rădulescu, Marius; Andronescu, Ecaterina; Holban, Alina M.; Vasile, Bogdan S.; Iordache, Florin; Mogoantă, Laurențiu; Mogoșanu, George D.; Grumezescu, Alexandru M.; Georgescu, Mihaela; Chifiriuc, Mariana C. 2016. "Antimicrobial Nanostructured Bioactive Coating Based on Fe3O4 and Patchouli Oil for Wound Dressing." Metals 6, no. 5: 103.
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