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Metals 2016, 6(5), 103; doi:10.3390/met6050103

Antimicrobial Nanostructured Bioactive Coating Based on Fe3O4 and Patchouli Oil for Wound Dressing

1
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, Bucharest 011061, Romania
2
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, Bucharest 011061, Romania
3
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane, Sector 5, Bucharest 77206, Romania
4
Research Institute of the University of Bucharest -ICUB: Life, Environmental and Earth Sciences, Spl. Independentei 91–95, Bucharest 0500088, Romania
5
Department of Fetal and Adult Stem Cell Therapy, Institute of Cellular Biology and Pathology of Romanian Academy, 8, B.P. Hasdeu, Bucharest 050568, Romania
6
Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
7
Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Hugo F. Lopez
Received: 8 March 2016 / Revised: 20 April 2016 / Accepted: 26 April 2016 / Published: 30 April 2016
(This article belongs to the Special Issue Metallic and Metal Oxide Nanoparticles: Novel Approaches)
View Full-Text   |   Download PDF [17646 KB, uploaded 30 April 2016]   |  

Abstract

The aim of this study was to develop a biocompatible coating for wound dressings, containing iron oxide nanoparticles functionalized with patchouli essential oil in order to obtain improved antimicrobial properties able to prevent biofilm development and consecutive associated infections. The bioactive coating was prepared by the co-precipitation of a precursor in an alkaline solution of patchouli oil. The prepared surface was characterized by XRD (X ray diffraction), TEM (transmission electron microscopy), SAED (selected area diffraction), SEM (scanning electron microscopy) and FT-IR (Fourier transform infrared spectroscopy). The bioevaluation of the obtained coating consisted in antimicrobial, as well as in vitro and in vivo biocompatibility and biodistribution assays. The obtained coating revealed a strong anti-biofilm activity maintained up to 72 h, as well as a low cytotoxicity on mammalian cells and a good biodistribution after intraperitoneal injection in mice. These results demonstrate the promising potential of the respective coatings for the management of wound infections and for the development of soft materials with improved resistance to microbial colonization. View Full-Text
Keywords: patchouli oil; wound dressing; magnetite; nanostructured surfaces patchouli oil; wound dressing; magnetite; nanostructured surfaces
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MDPI and ACS Style

Rădulescu, M.; Andronescu, E.; Holban, A.M.; Vasile, B.S.; Iordache, F.; Mogoantă, L.; Mogoșanu, G.D.; Grumezescu, A.M.; Georgescu, M.; Chifiriuc, M.C. Antimicrobial Nanostructured Bioactive Coating Based on Fe3O4 and Patchouli Oil for Wound Dressing. Metals 2016, 6, 103.

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