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Sports 2014, 2(3), 59-75; doi:10.3390/sports2030059

Effects of Endurance Exercise Training and Crataegus Extract WS® 1442 in Patients with Heart Failure with Preserved Ejection Fraction – A Randomized Controlled Trial

Department of Sport and Sport Science, House of Competence, Karlsruhe Institute of Technology, Karlsruhe, Germany, Engler-Bunte-Ring 15, Geb. 40.40, 76131 Karlsruhe, Germany
Kardiologie Waldstraße, Waldstraße 41-43, 76133 Karlsruhe, Germany
Dr. Willmar Schwabe GmbH & Co. KG, Bunsenstraße 6-10, 76275 Ettlingen, Germany
University of Applied Sciences Koblenz, RheinAhrCampus, Joseph-Rovan-Allee 2, 53424 Remagen, Germany
Author to whom correspondence should be addressed.
Received: 22 July 2014 / Revised: 22 August 2014 / Accepted: 14 September 2014 / Published: 24 September 2014
(This article belongs to the Special Issue Sports Medicine)
View Full-Text   |   Download PDF [497 KB, uploaded 24 September 2014]   |  


Impaired exercise capacity is the core symptom of heart failure with preserved ejection fraction (HFpEF). We assessed effects of exercise training and Crataegus extract WS 1442 in HFpEF and aimed to identify mechanisms of action in an exploratory trial (German Clinical Trials Register DRKS00000259). 140 sedentary HFpEF NYHA II patients on standard treatment received eight weeks of aerobic endurance training and half were randomized to WS 1442 900 mg/day. Symptoms, 2 km walking time (T2km), parameters of exercise tolerance, cardiac and vascular function, muscular efficiency and skeletal muscular haemoglobin oxygen saturation (SO2) measured during a treadmill protocol were captured at baseline and after eight weeks. Adverse events were recorded during the trial. Mechanisms of action were explored by correlation and path analyses of changes. Symptoms and exercise capacity improved with training, but correlations between improvements were low and path models were rejected. SO2 increased, decreased or undulated with increasing exercise intensity in individual patients and was not altered by training. WS 1442 improved T2km (-12.7% vs. -8.4%, p = 0.019), tended to improve symptoms and to pronounce SO2-decrease with increasing exercise, an indicator of oxygen utilisation. Endurance training and WS 1442 were safe and well tolerated in combination with standard drug treatment. View Full-Text
Keywords: heart failure; HFpEF; training; Crataegus; WS 1442; NIRS heart failure; HFpEF; training; Crataegus; WS 1442; NIRS

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Härtel, S.; Kutzner, C.; Westphal, E.; Limberger, M.; Burkart, M.; Ebner-Priemer, U.; Kohl-Bareis, M.; Bös, K. Effects of Endurance Exercise Training and Crataegus Extract WS® 1442 in Patients with Heart Failure with Preserved Ejection Fraction – A Randomized Controlled Trial. Sports 2014, 2, 59-75.

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