Next Article in Journal
A Statistical Perspective on Running with Prosthetic Lower-Limbs: An Advantage or Disadvantage?
Next Article in Special Issue
Effect of Level and Downhill Running on Breathing Efficiency
Previous Article in Journal
Acute Effects of Different Formats of Small-Sided and Conditioned Handball Games on Heart Rate Responses in Female Students During PE Classes
Article Menu

Export Article

Open AccessArticle
Sports 2014, 2(3), 59-75; doi:10.3390/sports2030059

Effects of Endurance Exercise Training and Crataegus Extract WS® 1442 in Patients with Heart Failure with Preserved Ejection Fraction – A Randomized Controlled Trial

1
Department of Sport and Sport Science, House of Competence, Karlsruhe Institute of Technology, Karlsruhe, Germany, Engler-Bunte-Ring 15, Geb. 40.40, 76131 Karlsruhe, Germany
2
Kardiologie Waldstraße, Waldstraße 41-43, 76133 Karlsruhe, Germany
3
Dr. Willmar Schwabe GmbH & Co. KG, Bunsenstraße 6-10, 76275 Ettlingen, Germany
4
University of Applied Sciences Koblenz, RheinAhrCampus, Joseph-Rovan-Allee 2, 53424 Remagen, Germany
*
Author to whom correspondence should be addressed.
Received: 22 July 2014 / Revised: 22 August 2014 / Accepted: 14 September 2014 / Published: 24 September 2014
(This article belongs to the Special Issue Sports Medicine)
View Full-Text   |   Download PDF [497 KB, uploaded 24 September 2014]   |  

Abstract

Impaired exercise capacity is the core symptom of heart failure with preserved ejection fraction (HFpEF). We assessed effects of exercise training and Crataegus extract WS 1442 in HFpEF and aimed to identify mechanisms of action in an exploratory trial (German Clinical Trials Register DRKS00000259). 140 sedentary HFpEF NYHA II patients on standard treatment received eight weeks of aerobic endurance training and half were randomized to WS 1442 900 mg/day. Symptoms, 2 km walking time (T2km), parameters of exercise tolerance, cardiac and vascular function, muscular efficiency and skeletal muscular haemoglobin oxygen saturation (SO2) measured during a treadmill protocol were captured at baseline and after eight weeks. Adverse events were recorded during the trial. Mechanisms of action were explored by correlation and path analyses of changes. Symptoms and exercise capacity improved with training, but correlations between improvements were low and path models were rejected. SO2 increased, decreased or undulated with increasing exercise intensity in individual patients and was not altered by training. WS 1442 improved T2km (-12.7% vs. -8.4%, p = 0.019), tended to improve symptoms and to pronounce SO2-decrease with increasing exercise, an indicator of oxygen utilisation. Endurance training and WS 1442 were safe and well tolerated in combination with standard drug treatment. View Full-Text
Keywords: heart failure; HFpEF; training; Crataegus; WS 1442; NIRS heart failure; HFpEF; training; Crataegus; WS 1442; NIRS
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Härtel, S.; Kutzner, C.; Westphal, E.; Limberger, M.; Burkart, M.; Ebner-Priemer, U.; Kohl-Bareis, M.; Bös, K. Effects of Endurance Exercise Training and Crataegus Extract WS® 1442 in Patients with Heart Failure with Preserved Ejection Fraction – A Randomized Controlled Trial. Sports 2014, 2, 59-75.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sports EISSN 2075-4663 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top