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Insects 2016, 7(4), 76; doi:10.3390/insects7040076

The Effect of West Nile Virus Infection on the Midgut Gene Expression of Culex pipiens quinquefasciatus Say (Diptera: Culicidae)

Florida Medical Entomology Laboratory, Department of Entomology and Nematology, University of Florida—IFAS, 200 9th Street Southeast, Vero Beach, FL 32962, USA
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Author to whom correspondence should be addressed.
Academic Editor: Brian T. Forschler
Received: 25 September 2016 / Revised: 27 November 2016 / Accepted: 6 December 2016 / Published: 19 December 2016
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Abstract

The interaction of the mosquito and the invading virus is complex and can result in physiological and gene expression alterations in the insect. The association of West Nile virus (WNV) and Culex pipiens quinquefasciatus mosquitoes results in measurable changes in gene expression; 22 gene products were shown previously to have altered expression. Sequence analysis of one product, CQ G1A1, revealed 100% amino acid identity to gram negative bacteria binding proteins (CPQGBP) in Cx. p. quinquefasciatus, Aedes aegypti (70%) and Anopheles gambiae (63%) that function in pathogen recognition. CQ G1A1 also was differentially expressed following WNV infection in two populations of Cx. p. quinquefasciatus colonized from Florida with known differences in vector competence for WNV and showed spatial and temporal gene expression differences in midgut, thorax, and carcass tissues. These data suggest gene expression of CQ G1A1 is influenced by WNV infection and the WNV infection-controlled expression differs between populations and tissues. View Full-Text
Keywords: gene expression; innate immunity; mosquito; gram negative bacteria binding protein; West Nile virus gene expression; innate immunity; mosquito; gram negative bacteria binding protein; West Nile virus
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MDPI and ACS Style

Smartt, C.T.; Shin, D.; Anderson, S.L. The Effect of West Nile Virus Infection on the Midgut Gene Expression of Culex pipiens quinquefasciatus Say (Diptera: Culicidae). Insects 2016, 7, 76.

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