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J. Pers. Med. 2016, 6(4), 19; doi:10.3390/jpm6040019

IDICAP: A Novel Tool for Integrating Drug Intervention Based on Cancer Panel

1
Department of Biology, Lafayette College, Easton, PA 18042, USA
2
Current address: Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Stephen B. Liggett
Received: 21 June 2016 / Revised: 5 September 2016 / Accepted: 18 October 2016 / Published: 28 October 2016
View Full-Text   |   Download PDF [3068 KB, uploaded 28 October 2016]   |  

Abstract

Cancer is a heterogeneous disease afflicting millions of people of all ages and their families worldwide. Tremendous resources have been and continue to be devoted to the development of cancer treatments that target the unique mutation profiles of patients, namely targeted cancer therapy. However, the sheer volume of drugs coupled with cancer heterogeneity becomes a challenge for physicians to prescribe effective therapies targeting patients’ unique genetic mutations. Developing a web service that allows clinicians as well as patients to identify effective drug therapies, both approved and experimental, would be helpful for both parties. We have developed an innovative web service, IDICAP, which stands for Integrated Drug Intervention for CAncer Panel. It uses genes that have been linked to a cancer type to search for drug and clinical trial information from ClinicalTrials.gov and DrugBank. IDICAP selects and integrates information pertaining to clinical trials, disease conditions, drugs under trial, locations of trials, drugs that are known to target the queried gene, and any known single nucleotide polymorphism (SNP) effects. We tested IDICAP by gene panels that contribute to breast cancer, ovarian cancer, and cancer in general. Clinical trials and drugs listed by our tool showed improved precision compared to the results from ClinicalTrials.gov and Drug Gene Interaction Database (DGIdb). Furthermore, IDICAP provides patients and doctors with a list of clinical facilities in their proximity, a characteristic that lends credence to the Precision Medicine Initiative launched by the White House in the United States in 2015. View Full-Text
Keywords: cancer gene panel; precision medicine; targeted cancer therapy; clinical trials; DrugBank; protein-protein interactions; DGIdb; OpenGeneMed cancer gene panel; precision medicine; targeted cancer therapy; clinical trials; DrugBank; protein-protein interactions; DGIdb; OpenGeneMed
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MDPI and ACS Style

Kosarek, N.; Ho, E.S. IDICAP: A Novel Tool for Integrating Drug Intervention Based on Cancer Panel. J. Pers. Med. 2016, 6, 19.

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