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J. Pers. Med. 2015, 5(3), 280-295; doi:10.3390/jpm5030280

Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach

Department of Psychology, Rice University, Houston, TX 77005, USA
Department of Symptoms Research, MD Anderson Cancer Center, Houston, TX 77030, USA
Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
Department of Psychology, University of Houston, Houston, TX 77004, USA
Department of Science, Technology, Engineering, and Mathematics, Dillard University, New Orleans, LA 70122, USA
Author to whom correspondence should be addressed.
Academic Editor: Jane M. Armer
Received: 7 April 2015 / Revised: 17 July 2015 / Accepted: 23 July 2015 / Published: 3 August 2015
(This article belongs to the Special Issue Long-term Cancer Survivorship)
View Full-Text   |   Download PDF [586 KB, uploaded 3 August 2015]


Being diagnosed and treated for breast cancer is emotionally and physically challenging. Breast cancer is the most commonly diagnosed cancer and the second leading cause of death for women in the United States. Accordingly, women with a breast cancer history are the largest group of female cancer survivors. Psychological stress substantially augments adverse autonomic, endocrine, and immune discharge, including enhanced production of proinflammatory cytokines. Importantly, inflammation is a key biological mechanism underlying the symptom cluster of pain, depression, fatigue, and sleep disturbances; there is also good evidence that inflammation contributes to breast cancer recurrence. Stress may exert direct effects on psychological and physiological risk processes. In this review, we take a biobehavioral approach to understanding predictors and mechanisms underlying somatic symptoms in breast cancer survivors. View Full-Text
Keywords: breast cancer survivors; inflammation; SES; chronic stressors; proinflammatory cytokine production; recurrence; fatigue; depression breast cancer survivors; inflammation; SES; chronic stressors; proinflammatory cytokine production; recurrence; fatigue; depression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fagundes, C.; LeRoy, A.; Karuga, M. Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach. J. Pers. Med. 2015, 5, 280-295.

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