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Diagnostics 2018, 8(1), 2; https://doi.org/10.3390/diagnostics8010002

Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities

1
Developmental Imaging & Biophysics Section, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK
2
Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, London WC1N 3BG, UK
3
Leonard Wolfson Experimental Neurology Centre, University College London Institute of Neurology, London WC1N 3BG, UK
*
Author to whom correspondence should be addressed.
Received: 27 November 2017 / Revised: 25 December 2017 / Accepted: 2 January 2018 / Published: 5 January 2018
(This article belongs to the Special Issue Functional and Molecular Imaging of Kidney and Urogenital Disease)
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Abstract

Tissue perfusion allows for delivery of oxygen and nutrients to tissues, and in the kidneys is also a key determinant of glomerular filtration. Quantification of regional renal perfusion provides a potential window into renal (patho) physiology. However, non-invasive, practical, and robust methods to measure renal perfusion remain elusive, particularly in the clinic. Arterial spin labeling (ASL), a magnetic resonance imaging (MRI) technique, is arguably the only available method with potential to meet all these needs. Recent developments suggest its viability for clinical application. This review addresses several of these developments and discusses remaining challenges with the emphasis on renal imaging in human subjects. View Full-Text
Keywords: magnetic resonance imaging; arterial spin labeling; renal MRI; renal ASL; chronic kidney disease; kidney perfusion magnetic resonance imaging; arterial spin labeling; renal MRI; renal ASL; chronic kidney disease; kidney perfusion
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Nery, F.; Gordon, I.; Thomas, D.L. Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities. Diagnostics 2018, 8, 2.

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