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Diagnostics 2017, 7(2), 22; doi:10.3390/diagnostics7020022

Ten Important Considerations for Ovarian Cancer Screening

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Kentucky Chandler Medical Center and the Markey Cancer Center, Lexington, KY 40536-0293, USA
Academic Editor: Andreas Kjaer
Received: 4 January 2017 / Revised: 5 April 2017 / Accepted: 7 April 2017 / Published: 13 April 2017
(This article belongs to the Special Issue Ovarian Cancer Screening)
View Full-Text   |   Download PDF [803 KB, uploaded 21 April 2017]   |  

Abstract

The unique intricacies of ovarian cancer screening and perspectives of different screening methods are presented as ten considerations that are examined. Included in these considerations are: (1) Deciding on the number of individuals to be screened; (2) Anticipating screening group reductions due to death; (3) Deciding on the duration and frequency of screening; (4) Deciding on an appropriate follow-up period after screening; (5) Deciding on time to surgery when malignancy is suspected; (6) Deciding on how screen-detected ovarian cancers are treated and by whom; (7) Deciding on how to treat the data of enrolled participants; (8) Deciding on the most appropriate way to assign disease-specific death; (9) Deciding how to avoid biases caused by enrollments that attract participants with late-stage disease who are either symptomatic or disposed by factors that are genetic, environmental or social; and (10) Deciding whether the screening tool or a screening process is being tested. These considerations are presented in depth along with illustrations of how they impact the outcomes of ovarian cancer screening. The considerations presented provide alternative explanations of effects that have an important bearing on interpreting ovarian screening outcomes. View Full-Text
Keywords: ovarian; cancer; screening; considerations ovarian; cancer; screening; considerations
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pavlik, E.J. Ten Important Considerations for Ovarian Cancer Screening. Diagnostics 2017, 7, 22.

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