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Diagnostics 2015, 5(2), 210-218; doi:10.3390/diagnostics5020210

Quantitative Assessment of Tissue Perfusion in Hepatocellular Carcinoma Using Perflubutane Dynamic Contrast-Enhanced Ultrasonography: A Preliminary Study

1
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Ishikawa 9200942, Japan
2
Department of Radiology, Tonami General Hospital, 16-1, Shintomicho, Tonami, Toyama 9391395, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Philippe L. Pereira
Received: 19 January 2015 / Revised: 28 April 2015 / Accepted: 14 May 2015 / Published: 20 May 2015
(This article belongs to the Special Issue Diagnosis of Hepatocellular Carcinoma)
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Abstract

Our purpose in this study was to assess the relationship between contrast signal intensity (CI) and concentration of perflubutane microbubbles in a phantom experiment, and to examine the feasibility of this technique for quantitative analysis of vascularity in hepatocellular carcinoma (HCC). Microbubble solutions of the perflubutane contrast agent were prepared by mixing with purified water. We examined the relationship between CI in dB units and the concentration. Moreover, seven HCC patients were examined using real-time dynamic contrast imaging. The perfusion index was calculated from time-intensity curves generated for both HCC and surrounding liver parenchyma. We observed a linear relationship between the CIdB and the concentration in the phantom study and a higher perfusion index in the HCC lesions relative to the surrounding liver parenchyma. Dynamic contrast-enhanced ultrasonography with perflubutane microbubbles, which exhibit linear and temporally stable characteristics under continuous ultrasound exposure, allows the collection of quantitative hemodynamic information regarding HCC. View Full-Text
Keywords: contrast-enhanced ultrasonography (CEUS); perflubutane; low mechanical index; hepatocellular carcinoma (HCC); perfusion index contrast-enhanced ultrasonography (CEUS); perflubutane; low mechanical index; hepatocellular carcinoma (HCC); perfusion index
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ohno, N.; Miyati, T.; Yamashita, M.; Narikawa, M. Quantitative Assessment of Tissue Perfusion in Hepatocellular Carcinoma Using Perflubutane Dynamic Contrast-Enhanced Ultrasonography: A Preliminary Study. Diagnostics 2015, 5, 210-218.

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