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Diagnostics 2014, 4(4), 153-164;

Current Challenges Towards the Development of a Blood Test for Parkinson’s Disease

The Cellular and Molecular Pharmacology Department, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064-3037, USA
Author to whom correspondence should be addressed.
Received: 9 September 2014 / Revised: 8 October 2014 / Accepted: 11 October 2014 / Published: 22 October 2014
(This article belongs to the Special Issue Biomarkers in Blood)
View Full-Text   |   Download PDF [683 KB, uploaded 22 October 2014]


Parkinson’ disease (PD) is the second most prevalent neurodegenerative disease worldwide. To date, there is no disease-modifying agent, and current medical treatment only provides symptomatic benefits. Early diagnosis of PD would be useful in clinical practice to identify patients for clinical trials, test potential drugs and neuroprotective agents and track their therapeutic effect. Considerable progress has been made in the discovery and validation of diagnostic biomarkers for PD. In particular, blood-based biomarkers have shown promise in identifying PD patients in samples from independent clinical trials. Evaluation of these biomarkers in de novo patients and individuals at risk for PD remains a top priority. Here, we review the current advances and challenges toward the clinical translation of these biomarkers into a blood-based test for PD. View Full-Text
Keywords: biomarkers; blood; Parkinson’s disease biomarkers; blood; Parkinson’s disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Santiago, J.A.; Potashkin, J.A. Current Challenges Towards the Development of a Blood Test for Parkinson’s Disease. Diagnostics 2014, 4, 153-164.

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