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Diagnostics, Volume 3, Issue 3 (September 2013), Pages 315-343

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Research

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Open AccessArticle A Multi-Camera System for Bioluminescence Tomography in Preclinical Oncology Research
Diagnostics 2013, 3(3), 325-343; doi:10.3390/diagnostics3030325
Received: 7 May 2013 / Revised: 13 June 2013 / Accepted: 26 June 2013 / Published: 9 July 2013
Cited by 1 | PDF Full-text (1499 KB) | HTML Full-text | XML Full-text
Abstract
Bioluminescent imaging (BLI) of cells expressing luciferase is a valuable noninvasive technique for investigating molecular events and tumor dynamics in the living animal. Current usage is often limited to planar imaging, but tomographic imaging can enhance the usefulness of this technique in [...] Read more.
Bioluminescent imaging (BLI) of cells expressing luciferase is a valuable noninvasive technique for investigating molecular events and tumor dynamics in the living animal. Current usage is often limited to planar imaging, but tomographic imaging can enhance the usefulness of this technique in quantitative biomedical studies by allowing accurate determination of tumor size and attribution of the emitted light to a specific organ or tissue. Bioluminescence tomography based on a single camera with source rotation or mirrors to provide additional views has previously been reported. We report here in vivo studies using a novel approach with multiple rotating cameras that, when combined with image reconstruction software, provides the desired representation of point source metastases and other small lesions. Comparison with MRI validated the ability to detect lung tumor colonization in mouse lung. Full article
(This article belongs to the Special Issue Advance in Molecular Diagnostics and Imaging)
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Review

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Open AccessReview Current Staging Procedures in Urinary Bladder Cancer
Diagnostics 2013, 3(3), 315-324; doi:10.3390/diagnostics3030315
Received: 17 May 2013 / Revised: 13 June 2013 / Accepted: 18 June 2013 / Published: 25 June 2013
Cited by 1 | PDF Full-text (327 KB) | HTML Full-text | XML Full-text
Abstract
Currently computed tomography (CT) represents the most widely used standard imaging modality in muscle-invasive urinary bladder cancer. Visualization of local tumor or depth of invasion as well as lymph node staging, however, is often impaired. Magnetic resonance imaging (MRI) with diffusion-weighted sequences, [...] Read more.
Currently computed tomography (CT) represents the most widely used standard imaging modality in muscle-invasive urinary bladder cancer. Visualization of local tumor or depth of invasion as well as lymph node staging, however, is often impaired. Magnetic resonance imaging (MRI) with diffusion-weighted sequences, determination of apparent diffusion coefficient (ADC) values or utilization of superparamagnetic iron nanoparticles potentially exhibits advantages in the assessment of local tumor or lymph node involvement and therefore might play a role in routine staging of urinary bladder cancer in the future. Likewise, positron emission tomography (PET) with the currently utilized tracers 18F-FDG, 11C-choline and 11C-acetate is investigated in bladder cancer patients—mostly in combination with diagnostic CT. Although promising results could be obtained for these PET/CT examinations in smaller series, their true value cannot be determined at present. Full article
(This article belongs to the Special Issue Advance in Molecular Diagnostics and Imaging)
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