Next Article in Journal
Modes of Fatty Acid Desaturation in Cyanobacteria: An Update
Next Article in Special Issue
Haloferax volcanii, as a Novel Tool for Producing Mammalian Olfactory Receptors Embedded in Archaeal Lipid Bilayer
Previous Article in Journal / Special Issue
The Adaptive Immune System of Haloferax volcanii
Article Menu

Export Article

Open AccessReview
Life 2015, 5(1), 538-553; doi:10.3390/life5010538

A Prokaryotic Twist on Argonaute Function

1
Institute of Molecular Medicine, Universitätsklinikum Schleswig-Holstein, University of Lübeck, 23538 Lübeck, Germany
2
Physikalische und Theoretische Chemie-NanoBioSciences, Technische Universität Braunschweig, Hans-Sommer-Strasse 10, 38106 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Hans-Peter Klenk, Michael W. W. Adams and Roger A. Garrett
Received: 21 December 2014 / Accepted: 5 February 2015 / Published: 16 February 2015
(This article belongs to the Special Issue Archaea: Evolution, Physiology, and Molecular Biology)
View Full-Text   |   Download PDF [961 KB, uploaded 14 May 2015]   |  

Abstract

Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of gene expression. Despite the mechanistic and structural similarities between archaeal, bacterial and eukaryotic Argonaute proteins, the biological function of bacterial and archaeal Argonautes has remained elusive. This review discusses new findings in the field that shed light on the structure and function of Argonaute. We especially focus on archaeal Argonautes when discussing the details of the structural and dynamic features in Argonaute that promote substrate recognition and cleavage, thereby revealing differences and similarities in Argonaute biology. View Full-Text
Keywords: Argonaute; archaeal; interference, guide strand Argonaute; archaeal; interference, guide strand
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Willkomm, S.; Zander, A.; Gust, A.; Grohmann, D. A Prokaryotic Twist on Argonaute Function. Life 2015, 5, 538-553.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Life EISSN 2075-1729 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top