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Life 2015, 5(1), 372-384; doi:10.3390/life5010372

From Formamide to RNA, the Path Is Tenuous but Continuous

1
Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy
2
Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic
3
CEITEC-Central European Institute of Technology, Masaryk University, Campus Bohunice, Kamenice 5, CZ-62500 Brno, Czech Republic
4
Istituto di Biologia e Patologia Molecolari, CNR, P.le Aldo Moro, 5, 00185 Rome, Italy
5
Dipartimento di Scienze Ecologiche e Biologiche Università della Tuscia Via San Camillo De Lellis, 01100 Viterbo, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Niles Lehman
Received: 30 September 2014 / Revised: 20 January 2015 / Accepted: 22 January 2015 / Published: 30 January 2015
(This article belongs to the Special Issue The Origins and Early Evolution of RNA)
View Full-Text   |   Download PDF [1086 KB, uploaded 30 January 2015]   |  

Abstract

Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination. View Full-Text
Keywords: formamide; nucleic bases; uridine; acyclonucleosides; 3',5' cyclic nucleotides; RNA; RNA polymerization; RNA origin; ribozymes; origin of life formamide; nucleic bases; uridine; acyclonucleosides; 3',5' cyclic nucleotides; RNA; RNA polymerization; RNA origin; ribozymes; origin of life
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pino, S.; Sponer, J.E.; Costanzo, G.; Saladino, R.; Mauro, E.D. From Formamide to RNA, the Path Is Tenuous but Continuous. Life 2015, 5, 372-384.

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