From Formamide to RNA, the Path Is Tenuous but Continuous
Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy
Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic
CEITEC-Central European Institute of Technology, Masaryk University, Campus Bohunice, Kamenice 5, CZ-62500 Brno, Czech Republic
Istituto di Biologia e Patologia Molecolari, CNR, P.le Aldo Moro, 5, 00185 Rome, Italy
Dipartimento di Scienze Ecologiche e Biologiche Università della Tuscia Via San Camillo De Lellis, 01100 Viterbo, Italy
Author to whom correspondence should be addressed.
Academic Editor: Niles Lehman
Received: 30 September 2014 / Revised: 20 January 2015 / Accepted: 22 January 2015 / Published: 30 January 2015
Reactions of formamide (NH2
COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.
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which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Pino, S.; Sponer, J.E.; Costanzo, G.; Saladino, R.; Mauro, E.D. From Formamide to RNA, the Path Is Tenuous but Continuous. Life 2015, 5, 372-384.
Pino S, Sponer JE, Costanzo G, Saladino R, Mauro ED. From Formamide to RNA, the Path Is Tenuous but Continuous. Life. 2015; 5(1):372-384.
Pino, Samanta; Sponer, Judit E.; Costanzo, Giovanna; Saladino, Raffaele; Mauro, Ernesto D. 2015. "From Formamide to RNA, the Path Is Tenuous but Continuous." Life 5, no. 1: 372-384.
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