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Antibodies 2018, 7(1), 2; https://doi.org/10.3390/antib7010002

Myelin Antigens and Antimyelin Antibodies

Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA
Received: 8 December 2017 / Revised: 20 December 2017 / Accepted: 22 December 2017 / Published: 2 January 2018
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Abstract

The purpose of this review is to provide an historical perspective on studies of serum derived antimyelin antibodies. Antimyelin antibodies can be defined by their action on myelinating organotypic nervous system tissue cultures and include demyelinating antibodies, which have destructive effects on myelin when applied to already myelinated cultures, and myelination inhibiting antibodies, which prevent myelin formation when applied to cultures prior to myelination. Myelin antigens were evaluated in animal studies for their ability to induce experimental allergic encephalomyelitis, an inflammatory demyelinating disease, and correlated with the induction of antimyelin antibodies. As tissue culture demyelinating activity was also found in sera from some patients with multiple sclerosis, a human inflammatory demyelinating disease, studies were undertaken to characterize the nature of the demyelinating factors. View Full-Text
Keywords: myelin; experimental allergic encephalomyelitis; myelin basic protein; immunoglobulin; myelin oligodendrocyte glycoprotein; multiple sclerosis myelin; experimental allergic encephalomyelitis; myelin basic protein; immunoglobulin; myelin oligodendrocyte glycoprotein; multiple sclerosis
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Seil, F.J. Myelin Antigens and Antimyelin Antibodies. Antibodies 2018, 7, 2.

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