Next Article in Journal / Special Issue
Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality
Previous Article in Journal
Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning
Article Menu

Export Article

Open AccessArticle
Antibodies 2017, 6(3), 11; doi:10.3390/antib6030011

Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein

1
HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA
2
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
3
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
4
Department of Immunology, UT Southwestern Medical Center Dallas, TX 75390, USA
5
Otsuka Pharmaceutical Co., Ltd., Osaka 540-0021, Japan
*
Author to whom correspondence should be addressed.
Received: 10 May 2017 / Revised: 14 June 2017 / Accepted: 1 August 2017 / Published: 23 August 2017
(This article belongs to the Special Issue Monoclonal Antibodies)
View Full-Text   |   Download PDF [2242 KB, uploaded 23 August 2017]   |  

Abstract

Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3—specific for the central repeat region—have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s. View Full-Text
Keywords: Plasmodium falciparum; circumsporozoite protein; CSP; monoclonal antibody; 2A10; 3C1; 3C2; 3D3 Plasmodium falciparum; circumsporozoite protein; CSP; monoclonal antibody; 2A10; 3C1; 3C2; 3D3
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, M.; Mandraju, R.; Rai, U.; Shiratsuchi, T.; Tsuji, M. Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein. Antibodies 2017, 6, 11.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top