Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein
AbstractMalaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3—specific for the central repeat region—have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s. View Full-Text
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Zhang, M.; Mandraju, R.; Rai, U.; Shiratsuchi, T.; Tsuji, M. Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein. Antibodies 2017, 6, 11.
Zhang M, Mandraju R, Rai U, Shiratsuchi T, Tsuji M. Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein. Antibodies. 2017; 6(3):11.Chicago/Turabian Style
Zhang, Min; Mandraju, Rajakumar; Rai, Urvashi; Shiratsuchi, Takayuki; Tsuji, Moriya. 2017. "Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein." Antibodies 6, no. 3: 11.
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