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Antibodies 2017, 6(1), 4; doi:10.3390/antib6010004

Neutrophil Extracellular Traps, Antiphospholipid Antibodies and Treatment

1
UNERA (Unit of Rheumatic and Autoimmune Diseases), Hospital Monte Sinaí, Miguel Cordero 6-111 y av. Solano, Cuenca, Ecuador
2
Department of Hematology and Hemostasis, CDB, Hospital Clinic, Villaroel 170, 08036 Barcelona, Catalonia, Spain
3
Faculty of Medicine and Health Science, Doctorate Programme “Medicine and Translational Research”, Barcelona University, Casanova, 143, 08036 Barcelona, Catalonia, Spain
4
Department of Investigation (DIUC-Dirección de Investigación de Universidad de Cuenca), Cuenca State University, Av. 12 de Abril y Agustin Cueva, Cuenca, Ecuador
*
Author to whom correspondence should be addressed.
Academic Editor: Ricard Cervera
Received: 1 January 2017 / Revised: 1 March 2017 / Accepted: 1 March 2017 / Published: 6 March 2017
(This article belongs to the Special Issue Antiphospholipid Antibodies and Syndrome)
View Full-Text   |   Download PDF [636 KB, uploaded 6 March 2017]   |  

Abstract

Neutrophil extracellular traps (NETs) are a network of extracellular fibers, compounds of chromatin, neutrophil DNA and histones, which are covered with antimicrobial enzymes with granular components. Autophagy and the production of reactive oxygen species (ROS) by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase are essential in the formation of NETs. There is increasing evidence that suggests that autoantibodies against beta-2-glycoprotein-1 (B2GP1) induce NETs and enhance thrombosis. Past research on new mechanisms of thrombosis formation in antiphospholipid syndrome (APS) has elucidated the pharmacokinetics of the most common medication in the treatment of the disease. View Full-Text
Keywords: neutrophil extracellular traps; NETosis; autophagy; antibodies; antiphospholipid syndrome neutrophil extracellular traps; NETosis; autophagy; antibodies; antiphospholipid syndrome
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Bravo-Barrera, J.; Kourilovitch, M.; Galarza-Maldonado, C. Neutrophil Extracellular Traps, Antiphospholipid Antibodies and Treatment. Antibodies 2017, 6, 4.

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