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Correction published on 27 April 2016, see Antibodies 2016, 5(2), 10.

Open AccessReview
Antibodies 2016, 5(1), 5; doi:10.3390/antib5010005

Cytokines in the Germinal Center Niche

1
Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
2
St Vincents Medical School, University of New South Wales, Sydney, NSW 2010, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Dent
Received: 17 November 2015 / Revised: 11 January 2016 / Accepted: 27 January 2016 / Published: 5 February 2016
(This article belongs to the Special Issue Follicular Helper T Cells)
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Abstract

Cytokines are small, secreted, glycoproteins that specifically affect the interactions and communications between cells. Cytokines are produced transiently and locally, acting in a paracrine or autocrine manner, and they are extremely potent, ligating high affinity cell surface receptors to elicit changes in gene expression and protein synthesis in the responding cell. Cytokines produced during the differentiation of T follicular helper (Tfh) cells and B cells within the germinal center (GC) niche play an important role in ensuring that the humoral immune response is robust, whilst retaining flexibility, during the generation of affinity matured antibodies. Cytokines produced by B cells, antigen presenting cells and stromal cells are important for the differentiation of Tfh cells and Tfh cell produced cytokines act both in an autocrine fashion to firm Tfh cell differentiation and in a paracrine fashion to support the differentiation of memory B cells and plasma cells. In this review, we discuss the role of cytokines during the GC reaction with a particular focus on the influence of cytokines on Tfh cells. View Full-Text
Keywords: cytokines; germinal center; T follicular helper cells; interleukin cytokines; germinal center; T follicular helper cells; interleukin
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Jandl, C.; King, C. Cytokines in the Germinal Center Niche. Antibodies 2016, 5, 5.

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