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Antibodies 2016, 5(1), 2; doi:10.3390/antib5010002

Autoantibodies in SLE: Specificities, Isotypes and Receptors

Centre de Recherche sur l’Inflammation, INSERM UMR1149, CNRS ERL8252, Université Paris Diderot, Sorbonne Paris Cité, Faculté de Médecine site Bichat, Laboratoire d’Excellence Inflamex, DHU FIRE, Paris 75018, France
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Author to whom correspondence should be addressed.
Academic Editor: Christiane Hampe
Received: 25 September 2015 / Revised: 9 December 2015 / Accepted: 11 December 2015 / Published: 4 January 2016
(This article belongs to the Special Issue Auto-Antibody and Autoimmune Disease)
View Full-Text   |   Download PDF [890 KB, uploaded 4 January 2016]

Abstract

Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-antibodies which recognize several cellular components. The production of these self-reactive antibodies fluctuates during the course of the disease and the involvement of different antibody-secreting cell populations are considered highly relevant for the disease pathogenesis. These cells are developed and stimulated through different ways leading to the secretion of a variety of isotypes, affinities and idiotypes. Each of them has a particular mechanism of action binding to a specific antigen and recognized by distinct receptors. The effector responses triggered lead to a chronic tissue inflammation. DsDNA autoantibodies are the most studied as well as the first in being characterized for its pathogenic role in Lupus nephritis. However, others are of growing interest since they have been associated with other organ-specific damage, such as anti-NMDAR antibodies in neuropsychiatric clinical manifestations or anti-β2GP1 antibodies in vascular symptomatology. In this review, we describe the different auto-antibodies reported to be involved in SLE. How autoantibody isotypes and affinity-binding to their antigen might result in different pathogenic responses is also discussed. View Full-Text
Keywords: autoantibodies; isotypes; lupus; SLE; Fc receptors autoantibodies; isotypes; lupus; SLE; Fc receptors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dema, B.; Charles, N. Autoantibodies in SLE: Specificities, Isotypes and Receptors. Antibodies 2016, 5, 2.

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