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Antibodies 2015, 4(4), 409-425; doi:10.3390/antib4040409

Regenerating Gene Protein as a Novel Autoantigen in the Pathogenesis of Sjögren’s Syndrome

1
The Center for Rheumatic Diseases, Nara Medical University Hospital, 840 Shijo-cho, Kashihara 634-8522, Japan
2
Department of General Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan
3
Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan
4
Department of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Dimiter S. Dimitrov
Received: 27 August 2015 / Revised: 9 November 2015 / Accepted: 30 November 2015 / Published: 7 December 2015
(This article belongs to the Special Issue Auto-Antibody and Autoimmune Disease)
View Full-Text   |   Download PDF [1097 KB, uploaded 7 December 2015]   |  

Abstract

Sjögren’s syndrome, an autoimmune disease characterized by exocrine gland dysfunction leading to dry mouth and dry eye diseases, is typified by lymphoplasmacytic infiltrations and a progressive destruction of the salivary and lacrimal glands. Despite an ever-increasing focus on identifying the underlying etiology of Sjögren’s syndrome, the factors that initiate this autoimmune disease and the mechanisms that cause the subsequent exocrine gland dysfunction remain a mystery. The original explanatory concept for the pathogenesis of Sjögren’s syndrome proposed a specific, self-perpetuating, immune-mediated loss of acinar and ductal cells as the principal cause of salivary gland dysfunction. We highlight the possible involvement of regenerating gene (Reg) in the regeneration and destruction of salivary gland acinar and ductal cells in Sjögren’s syndrome. The Reg gene was originally isolated as a gene specifically overexpressed in regenerating pancreatic islets and constitutes a growth factor family (Reg family). We describe how salivary gland dysfunction is initiated and maintained and how it can be regenerated or progressed, mediated by the Reg gene, Reg protein, and anti-REG autoantibodies in Sjögren’s syndrome. View Full-Text
Keywords: regenerating gene; anti-REG autoantibody; ductal epithelial cells; interleukin-6; Sjögren’s syndrome; Janus kinase; signal transducer and activator of transcription regenerating gene; anti-REG autoantibody; ductal epithelial cells; interleukin-6; Sjögren’s syndrome; Janus kinase; signal transducer and activator of transcription
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fujimoto, T.; Yoshimoto, K.; Fujimura, T.; Takeda, M.; Yamauchi, A.; Itaya-Hironaka, A.; Takasawa, S. Regenerating Gene Protein as a Novel Autoantigen in the Pathogenesis of Sjögren’s Syndrome. Antibodies 2015, 4, 409-425.

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