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Antibodies 2014, 3(4), 289-302; doi:10.3390/antib3040289

Antibody Fragments Defining Biologically Relevant Conformations of Target Proteins

UCB, 216 Bath Road, Slough, SL1 3WE UK
Received: 10 November 2014 / Revised: 2 December 2014 / Accepted: 8 December 2014 / Published: 11 December 2014
(This article belongs to the Special Issue Antibody Constructs)
View Full-Text   |   Download PDF [830 KB, uploaded 11 December 2014]   |  

Abstract

Antibody fragments have long been used as chaperones in crystallography, but have more recently been applied to the definition of biologically relevant conformations among the dynamic ensemble of target protein conformational sampling. This review charts the progress being made in understanding function in the context of structure using this approach, and highlights new opportunities for drug discovery. View Full-Text
Keywords: antibody fragments; conformation; definition antibody fragments; conformation; definition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lawson, A.D.G. Antibody Fragments Defining Biologically Relevant Conformations of Target Proteins. Antibodies 2014, 3, 289-302.

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