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Antibodies 2013, 2(3), 415-425; doi:10.3390/antib2030415
Review

In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells

, ,  and *
Received: 13 March 2013; in revised form: 6 June 2013 / Accepted: 19 June 2013 / Published: 27 June 2013
(This article belongs to the Special Issue Bispecific Antibodies for Dual Targeting Strategies)
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Abstract: Engineered Fc-lacking bispecific antibodies have shown an exceptionally high potency for recruiting lymphocyte effector cells and enhancing antitumor activity, which is under evaluation in several clinical trials. However, current treatment regimens raise some issues that should be considered, such as the high cost of clinical-grade bispecific antibodies and the achievement of sustained therapeutic plasma levels. The use of gene transfer methods may circumvent problems related to large-scale production and purification, and result in sustained therapeutic plasma concentrations of the Fc-lacking bispecific antibodies. In fact, terminally differentiated cells and non-terminally differentiated cells can be genetically modified to secrete functionally active bispecific antibodies exerting clear anti-tumor effects. This review highlights the relevance of different promising strategies for in vivo delivery of therapeutic bispecific antibodies.
Keywords: bispecific antibodies; in vivo secretion; gene therapy; cell-based therapy; immunotherapeutic organoids; immunotherapeutic neovessels bispecific antibodies; in vivo secretion; gene therapy; cell-based therapy; immunotherapeutic organoids; immunotherapeutic neovessels
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Compte, M.; Nuñez-Prado, N.; Sanz, L.; Alvarez-Vallina, L. In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells. Antibodies 2013, 2, 415-425.

AMA Style

Compte M, Nuñez-Prado N, Sanz L, Alvarez-Vallina L. In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells. Antibodies. 2013; 2(3):415-425.

Chicago/Turabian Style

Compte, Marta; Nuñez-Prado, Natalia; Sanz, Laura; Alvarez-Vallina, Luis. 2013. "In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells." Antibodies 2, no. 3: 415-425.

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