Epigenetic Control of Pancreatic Regeneration in Diabetes
AbstractBoth type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development, making use of diverse cell sources or converting pre-existing pancreatic cells. Despite impressive progresses and promising successes, it appears that we still need to gain further insight into the molecular mechanisms underlying β-cell development. This becomes even more obvious with the emergence of a relatively new field of research, epigenetics. The current review therefore focuses on the latest advances in this field in the context of β-cell (neo-)genesis research. View Full-Text
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Balaji, S.; Napolitano, T.; Silvano, S.; Friano, M.E.; Garrido-Utrilla, A.; Atlija, J.; Collombat, P. Epigenetic Control of Pancreatic Regeneration in Diabetes. Genes 2018, 9, 448.
Balaji S, Napolitano T, Silvano S, Friano ME, Garrido-Utrilla A, Atlija J, Collombat P. Epigenetic Control of Pancreatic Regeneration in Diabetes. Genes. 2018; 9(9):448.Chicago/Turabian Style
Balaji, Shruti; Napolitano, Tiziana; Silvano, Serena; Friano, Marika E.; Garrido-Utrilla, Anna; Atlija, Josipa; Collombat, Patrick. 2018. "Epigenetic Control of Pancreatic Regeneration in Diabetes." Genes 9, no. 9: 448.
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