Pervasive Modulation of Obesity Risk by the Environment and Genomic Background
AbstractThe prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a major role for environmental risk factors. Obesity constitutes a case example of a modern trait shaped by contemporary environment, although with considerable debates about the extent to which gene-by-environment (G×E) interactions accentuate obesity risk in individuals following obesogenic lifestyles. Although interaction effects have been robustly confirmed at the FTO locus, accumulating evidence at the genome-wide level implicates a role for polygenic risk-by-environment interactions. Through a variety of analyses using the UK Biobank, we confirm that the genomic background plays a major role in shaping the expressivity of alleles that increase body mass index (BMI). View Full-Text
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Nagpal, S.; Gibson, G.; Marigorta, U.M. Pervasive Modulation of Obesity Risk by the Environment and Genomic Background. Genes 2018, 9, 411.
Nagpal S, Gibson G, Marigorta UM. Pervasive Modulation of Obesity Risk by the Environment and Genomic Background. Genes. 2018; 9(8):411.Chicago/Turabian Style
Nagpal, Sini; Gibson, Greg; Marigorta, Urko M. 2018. "Pervasive Modulation of Obesity Risk by the Environment and Genomic Background." Genes 9, no. 8: 411.
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