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Genes 2018, 9(1), 16; doi:10.3390/genes9010016

SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma

1
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
2
National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
3
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
4
Center for Molecular Medicine, Key Laboratory of Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
5
Department of Medical Oncology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 December 2017 / Revised: 1 January 2018 / Accepted: 2 January 2018 / Published: 4 January 2018
(This article belongs to the Special Issue Computational Approaches for Disease Gene Identification)
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Abstract

There is increasing evidence for the contribution of synuclein alpha (SNCA) to the etiology of neurological disorders, such as Parkinson’s disease (PD). However, little is known about the detailed role of SNCA in human cancers, especially lung cancers. Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive bioinformatics analyses of data obtained from the Oncomine platform, the human protein atlas (HPA) project and the cancer cell line encyclopedia (CCLE) demonstrated that SNCA expression was significantly reduced in both ADC tissues and cancer cells. The results of relevant clinical studies indicated that down-regulation of SNCA was statistically correlated with shorter overall survival time and post-progression survival time. Through analysis of datasets obtained from the Gene Expression Omnibus database, significant low levels of SNCA were identified in cisplatin-resistant ADC cells. Moreover, small interfering RNA (siRNA)-mediated knockdown of protein tyrosine kinase 7 (PTK7) elevated the expression of SNCA in the ADC cell lines H1299 and H2009. Our work demonstrates that low levels of SNCA are specifically found in ADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determination of the role of SNCA in ADC biology would give us some insightful information for further investigations. View Full-Text
Keywords: SNCA; lung adenocarcinoma; overall survival; therapeutic target SNCA; lung adenocarcinoma; overall survival; therapeutic target
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Yan, Y.; Xu, Z.; Hu, X.; Qian, L.; Li, Z.; Zhou, Y.; Dai, S.; Zeng, S.; Gong, Z. SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma. Genes 2018, 9, 16.

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