Next Article in Journal
The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype
Next Article in Special Issue
CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
Previous Article in Journal
DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients
Previous Article in Special Issue
Variability of DNA Methylation within Schizophrenia Risk Loci across Subregions of Human Hippocampus
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Genes 2017, 8(5), 145; doi:10.3390/genes8050145

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Dennis R. Grayson
Received: 29 March 2017 / Revised: 8 May 2017 / Accepted: 12 May 2017 / Published: 17 May 2017
(This article belongs to the Special Issue Role of Epigenetic Gene Regulation in Brain Function)
View Full-Text   |   Download PDF [1277 KB, uploaded 17 May 2017]   |  

Abstract

High-grade astrocytoma of WHO grade 4 termed glioblastoma multiforme (GBM) is a common human brain tumor with poor patient outcome. Astrocytoma demonstrates two known telomere maintenance mechanisms (TMMs) based on telomerase activity (TA) and on alternative lengthening of telomeres (ALT). ALT is associated with lower tumor grades and better outcome. In contrast to ALT, regulation of TA in tumors by direct mutation and epigenetic activation of the hTERT promoter is well established. Here, we summarize the genetic background of TMMs in non-malignant cells and in cancer, in addition to clinical and pathological features of gliomas. Furthermore, we present new evidence for epigenetic mechanisms (EMs) involved in regulation of ALT and TA with special emphasis on human diffuse gliomas as potential therapeutic drug targets. We discuss the role of TMM associated telomeric chromatin factors such as DNA and histone modifying enzymes and non-coding RNAs including microRNAs and long telomeric TERRA transcripts. View Full-Text
Keywords: telomere maintenance; high grade glioma; epigenetic therapy; CpG DNA methylation; chromatin modification; histone methylation and acetylation; histone deacetylase; miRNA; telomeric repeat-containing RNA telomere maintenance; high grade glioma; epigenetic therapy; CpG DNA methylation; chromatin modification; histone methylation and acetylation; histone deacetylase; miRNA; telomeric repeat-containing RNA
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Naderlinger, E.; Holzmann, K. Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas. Genes 2017, 8, 145.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top