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Genes 2017, 8(3), 85; doi:10.3390/genes8030085

Historical and Clinical Experiences of Gene Therapy for Solid Cancers in China

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Authors to whom correspondence should be addressed.
Academic Editor: Michael Barry
Received: 9 October 2016 / Accepted: 19 January 2017 / Published: 24 February 2017
(This article belongs to the Special Issue Gene Therapy)
View Full-Text   |   Download PDF [686 KB, uploaded 27 February 2017]   |  


Based on the theoretical and clinical development of modern medicines, gene therapy has been a promising treatment strategy for cancer and other diseases. The practice of gene therapy is nearly 27 years old, since the first authorized gene transfer study took place at the National Institute of Health in 1989. However, gene therapy was not readily adopted worldwide, until recently. Several gene therapy clinical trials have been carried out in China since 1998, and medical research in China has flourished. In this report, we review the history of gene therapy in China, focusing on treatment protocol, the administration cycle, dosage calculation, and the evaluation of therapeutic effects, in order to provide more information for the additional development of this promising treatment strategy. View Full-Text
Keywords: gene therapy; history; clinical trial gene therapy; history; clinical trial

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, B.; Gao, N.; Zhang, Z.; Chen, Q.; Li, L.; Li, Y. Historical and Clinical Experiences of Gene Therapy for Solid Cancers in China. Genes 2017, 8, 85.

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