Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis
AbstractSmall regulatory RNAs (sRNAs) of Shigella dysenteriae and other pathogens are vital for the regulation of virulence-associated genes and processes. Here, we characterize RyfA1, one member of a sibling pair of sRNAs produced by S. dysenteriae. Unlike its nearly identical sibling molecule, RyfA2, predicted to be encoded almost exclusively by non-pathogenic species, the presence of a gene encoding RyfA1, or a RyfA1-like molecule, is strongly correlated with virulence in a variety of enteropathogens. In S. dysenteriae, the overproduction of RyfA1 negatively impacts the virulence-associated process of cell-to-cell spread as well as the expression of ompC, a gene encoding a major outer membrane protein important for the pathogenesis of Shigella. Interestingly, the production of RyfA1 is controlled by a second sRNA, here termed RyfB1, the first incidence of one regulatory small RNA controlling another in S. dysenteriae or any Shigella species. View Full-Text
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Fris, M.E.; Broach, W.H.; Klim, S.E.; Coschigano, P.W.; Carroll, R.K.; Caswell, C.C.; Murphy, E.R. Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis. Genes 2017, 8, 50.
Fris ME, Broach WH, Klim SE, Coschigano PW, Carroll RK, Caswell CC, Murphy ER. Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis. Genes. 2017; 8(2):50.Chicago/Turabian Style
Fris, Megan E.; Broach, William H.; Klim, Sarah E.; Coschigano, Peter W.; Carroll, Ronan K.; Caswell, Clayton C.; Murphy, Erin R. 2017. "Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis." Genes 8, no. 2: 50.