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Genes 2017, 8(12), 348; doi:10.3390/genes8120348

Non-Coding RNAs in Pediatric Airway Diseases

Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-512 Poznan, Poland
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Received: 31 October 2017 / Revised: 18 November 2017 / Accepted: 21 November 2017 / Published: 27 November 2017
(This article belongs to the Special Issue Non-coding RNAs)
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Abstract

Non-coding RNAs (ncRNAs) are involved in the regulation of numerous biological processes and pathways and therefore have been extensively studied in human diseases. Previous reports have shown that non-coding RNAs play a crucial role in the pathogenesis and aberrant regulation of respiratory diseases. The altered expression of microRNAs (miRNAs) and long non-coding RNAs in blood and also locally in sputum or exhaled breath condensate influences lung function, immune response, and disease phenotype and may be used for the development of biomarkers specific for airway disease. In this review, we provide an overview of the recent works studying the non-coding RNAs in airway diseases, with a particular focus on chronic respiratory diseases of childhood. We have chosen the most common chronic respiratory condition—asthma—and the most severe, chronic disease of the airways—cystic fibrosis. Study of the altered expression of non-coding RNAs in these diseases may be key to better understanding their pathogenesis and improving diagnosis, while also holding promise for the development of therapeutic strategies using the regulatory potential of non-coding RNAs. View Full-Text
Keywords: miRNA; long non-coding RNA; asthma; cystic fibrosis; viral infection; biomarkers miRNA; long non-coding RNA; asthma; cystic fibrosis; viral infection; biomarkers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Narożna, B.; Langwiński, W.; Szczepankiewicz, A. Non-Coding RNAs in Pediatric Airway Diseases. Genes 2017, 8, 348.

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