Next Article in Journal
The Chloroplast Genome of Symplocarpus renifolius: A Comparison of Chloroplast Genome Structure in Araceae
Next Article in Special Issue
scRNASeqDB: A Database for RNA-Seq Based Gene Expression Profiles in Human Single Cells
Previous Article in Journal
Origin and Evolution of the Neo-Sex Chromosomes in Pamphagidae Grasshoppers through Chromosome Fusion and Following Heteromorphization
Previous Article in Special Issue
Gene Regulatory Network Rewiring in the Immune Cells Associated with Cancer
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Genes 2017, 8(11), 321; doi:10.3390/genes8110321

Comprehensive Profiling of lincRNAs in Lung Adenocarcinoma of Never Smokers Reveals Their Roles in Cancer Development and Prognosis

Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Department of Pulmonary Medicine, People’s Hospital of Henan Province, Zhengzhou 450003, China
Authors to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 28 October 2017 / Accepted: 6 November 2017 / Published: 13 November 2017
(This article belongs to the Special Issue Integrative Genomics and Systems Medicine in Cancer)
View Full-Text   |   Download PDF [2877 KB, uploaded 13 November 2017]   |  


Long intergenic non-coding RNA (lincRNA) is a family of gene transcripts, the functions of which are largely unknown. Although cigarette smoking is the main cause for lung cancer, lung cancer in non-smokers is a separate entity and its underlying cause is little known. Growing evidence suggests lincRNAs play a significant role in cancer development and progression; however, such data is lacking for lung cancer in non-smokers, or those who have never smoked. This study conducted comprehensive profiling of lincRNAs from RNA sequencing (RNA-seq) data of non-smoker patients with lung adenocarcinoma. Both known and novel lincRNAs distinctly segregated tumors from normal tissues. Approximately one third of lincRNAs were differentially expressed between tumors and normal samples and most of them were coordinated with their putative protein gene targets. More importantly, lincRNAs defined two clusters of tumors that were associated with tumor aggressiveness and patient survival. We identified a subset of lincRNAs that were differentially expressed and also associated with patient survival. Very high concordance (R2 = 0.9) was observed for the differentially expressed lincRNAs in the Cancer Genome Atlas (TCGA) validation set of 85 transcriptomes and the lincRNAs associated with survival from the discovery set were similarly predictive in the validation set. These lincRNAs warrant further investigation as potential diagnostic and prognostic markers. View Full-Text
Keywords: long intergenic non-coding RNA; never smokers; lung adenocarcinoma; RNA-sequencing long intergenic non-coding RNA; never smokers; lung adenocarcinoma; RNA-sequencing

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, Y.; Wang, Z.; Nair, A.; Song, W.; Yang, P.; Zhang, X.; Sun, Z. Comprehensive Profiling of lincRNAs in Lung Adenocarcinoma of Never Smokers Reveals Their Roles in Cancer Development and Prognosis. Genes 2017, 8, 321.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top