RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse
AbstractPseudouridine is the most abundant modification found in RNA. Today, thanks to next-generation sequencing techniques used in the detection of RNA modifications, pseudouridylation sites have been described in most eukaryotic RNA classes. In the present review, we will first consider the available information on the functional roles of pseudouridine(s) in different RNA species. We will then focus on how alterations in the pseudouridylation process may be connected with a series of human pathologies, including inherited disorders, cancer, diabetes, and viral infections. Finally, we will discuss how the availability of novel technical approaches are likely to increase the knowledge in this field. View Full-Text
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Penzo, M.; Guerrieri, A.N.; Zacchini, F.; Treré, D.; Montanaro, L. RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse. Genes 2017, 8, 301.
Penzo M, Guerrieri AN, Zacchini F, Treré D, Montanaro L. RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse. Genes. 2017; 8(11):301.Chicago/Turabian Style
Penzo, Marianna; Guerrieri, Ania N.; Zacchini, Federico; Treré, Davide; Montanaro, Lorenzo. 2017. "RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse." Genes 8, no. 11: 301.
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