Next Article in Journal
Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips
Previous Article in Journal
Textile Hemp vs. Salinity: Insights from a Targeted Gene Expression Analysis
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Genes 2017, 8(10), 243; doi:10.3390/genes8100243

Genetic Association between Amyotrophic Lateral Sclerosis and Cancer

1
Department of Physics, Chuo University, 1-13-27 Kasuga, Bunky-ku, Tokyo 112-8551, Japan
2
Institute of Statistics, National Chiao Tung University, Hsinchu 30010, Taiwan
*
Author to whom correspondence should be addressed.
Received: 12 August 2017 / Revised: 15 September 2017 / Accepted: 22 September 2017 / Published: 27 September 2017
View Full-Text   |   Download PDF [807 KB, uploaded 27 September 2017]   |  

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. An ALS drug, Riluzole, has been shown to induce two different anticancer effects on hepatocellular carcinoma (HCC). In light of this finding, we explore the relationship between ALS and cancer, especially for HCC, from the molecular biological viewpoint. We establish biomarkers that can discriminate between ALS patients and healthy controls. A principal component analysis (PCA) based unsupervised feature extraction (FE) is used to find gene biomarkers of ALS based on microarray gene expression data. Based on this method, 101 probes were selected as biomarkers for ALS with 95% high accuracy to discriminate between ALS patients and controls. Most of the genes corresponding to these probes are shown to be related to various cancers. These findings might provide a new insight for developing new therapeutic options or drugs for both ALS and cancer. View Full-Text
Keywords: amyotrophic lateral sclerosis; biomarker; cancer; gene; microarray amyotrophic lateral sclerosis; biomarker; cancer; gene; microarray
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Taguchi, Y.-H.; Wang, H. Genetic Association between Amyotrophic Lateral Sclerosis and Cancer. Genes 2017, 8, 243.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top