Next Article in Journal
A Spatial Control for Correct Timing of Gene Expression during the Escherichia coli Cell Cycle
Next Article in Special Issue
Non-Coding RNAs in Lung Cancer: Contribution of Bioinformatics Analysis to the Development of Non-Invasive Diagnostic Tools
Previous Article in Journal
RNA Editing and Its Molecular Mechanism in Plant Organelles
Previous Article in Special Issue
miR-203 and miR-320 Regulate Bone Morphogenetic Protein-2-Induced Osteoblast Differentiation by Targeting Distal-Less Homeobox 5 (Dlx5)
Article Menu

Export Article

Open AccessReview
Genes 2017, 8(1), 6; doi:10.3390/genes8010006

Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases

1
Molecular Morphology Laboratory, AC Camargo Cancer Center, São Paulo 01508-010, Brazil
2
Molecular Gynecology Laboratory, Gynecologic Department, Federal University of São Paulo, São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: George A. Calin and Muller Fabbri
Received: 15 September 2016 / Revised: 20 November 2016 / Accepted: 14 December 2016 / Published: 23 December 2016
(This article belongs to the Special Issue microRNAs and Other Non-Coding RNAs in Human Diseases)
View Full-Text   |   Download PDF [1518 KB, uploaded 23 December 2016]   |  

Abstract

Tobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways—primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases. View Full-Text
Keywords: noncoding RNAs; microRNAs; long noncoding RNAs; tobacco; alcohol; cancer; chronic obstructive pulmonary disease; cardiovascular diseases noncoding RNAs; microRNAs; long noncoding RNAs; tobacco; alcohol; cancer; chronic obstructive pulmonary disease; cardiovascular diseases
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Soares do Amaral, N.; Cruz e Melo, N.; de Melo Maia, B.; Malagoli Rocha, R. Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases. Genes 2017, 8, 6.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top