Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review
AbstractBurkholderia cepacia complex (Bcc) bacteria emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients. Their eradication is very difficult due to the high level of intrinsic resistance to clinically relevant antibiotics. Bcc bacteria have large and complex genomes, composed of two to four replicons, with variable numbers of insertion sequences. The complexity of Bcc genomes confers a high genomic plasticity to these bacteria, allowing their adaptation and survival to diverse habitats, including the human host. In this work, we review results from recent studies using omics approaches to elucidate in vivo adaptive strategies and virulence gene regulation expression of Bcc bacteria when infecting the human host or subject to conditions mimicking the stressful environment of the cystic fibrosis lung. View Full-Text
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Sousa, S.A.; Feliciano, J.R.; Pita, T.; Guerreiro, S.I.; Leitão, J.H. Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review. Genes 2017, 8, 43.
Sousa SA, Feliciano JR, Pita T, Guerreiro SI, Leitão JH. Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review. Genes. 2017; 8(1):43.Chicago/Turabian Style
Sousa, Sílvia A.; Feliciano, Joana R.; Pita, Tiago; Guerreiro, Soraia I.; Leitão, Jorge H. 2017. "Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review." Genes 8, no. 1: 43.
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