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Genes 2017, 8(1), 43; doi:10.3390/genes8010043

Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review

Institute for Bioengineering and Biosciences (IBB), and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
Authors to whom correspondence should be addressed.
Academic Editor: Helen J. Wing
Received: 7 November 2016 / Revised: 11 January 2017 / Accepted: 12 January 2017 / Published: 19 January 2017
(This article belongs to the Special Issue Virulence Gene Regulation in Bacteria)
View Full-Text   |   Download PDF [479 KB, uploaded 19 January 2017]   |  


Burkholderia cepacia complex (Bcc) bacteria emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients. Their eradication is very difficult due to the high level of intrinsic resistance to clinically relevant antibiotics. Bcc bacteria have large and complex genomes, composed of two to four replicons, with variable numbers of insertion sequences. The complexity of Bcc genomes confers a high genomic plasticity to these bacteria, allowing their adaptation and survival to diverse habitats, including the human host. In this work, we review results from recent studies using omics approaches to elucidate in vivo adaptive strategies and virulence gene regulation expression of Bcc bacteria when infecting the human host or subject to conditions mimicking the stressful environment of the cystic fibrosis lung. View Full-Text
Keywords: Burkholderia cepacia complex (Bcc); cystic fibrosis (CF); post-genomic approaches; adaptive strategies Burkholderia cepacia complex (Bcc); cystic fibrosis (CF); post-genomic approaches; adaptive strategies

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sousa, S.A.; Feliciano, J.R.; Pita, T.; Guerreiro, S.I.; Leitão, J.H. Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review. Genes 2017, 8, 43.

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