Centromere Stability: The Replication Connection
AbstractThe fission yeast centromere, which is similar to metazoan centromeres, contains highly repetitive pericentromere sequences that are assembled into heterochromatin. This is required for the recruitment of cohesin and proper chromosome segregation. Surprisingly, the pericentromere replicates early in the S phase. Loss of heterochromatin causes this domain to become very sensitive to replication fork defects, leading to gross chromosome rearrangements. This review examines the interplay between components of DNA replication, heterochromatin assembly, and cohesin dynamics that ensures maintenance of genome stability and proper chromosome segregation. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Forsburg, S.L.; Shen, K.-F. Centromere Stability: The Replication Connection. Genes 2017, 8, 37.
Forsburg SL, Shen K-F. Centromere Stability: The Replication Connection. Genes. 2017; 8(1):37.Chicago/Turabian Style
Forsburg, Susan L.; Shen, Kuo-Fang. 2017. "Centromere Stability: The Replication Connection." Genes 8, no. 1: 37.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.