Centromere Stability: The Replication Connection
AbstractThe fission yeast centromere, which is similar to metazoan centromeres, contains highly repetitive pericentromere sequences that are assembled into heterochromatin. This is required for the recruitment of cohesin and proper chromosome segregation. Surprisingly, the pericentromere replicates early in the S phase. Loss of heterochromatin causes this domain to become very sensitive to replication fork defects, leading to gross chromosome rearrangements. This review examines the interplay between components of DNA replication, heterochromatin assembly, and cohesin dynamics that ensures maintenance of genome stability and proper chromosome segregation. View Full-Text
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Forsburg, S.L.; Shen, K.-F. Centromere Stability: The Replication Connection. Genes 2017, 8, 37.
Forsburg SL, Shen K-F. Centromere Stability: The Replication Connection. Genes. 2017; 8(1):37.Chicago/Turabian Style
Forsburg, Susan L.; Shen, Kuo-Fang. 2017. "Centromere Stability: The Replication Connection." Genes 8, no. 1: 37.