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Genes 2017, 8(1), 37; doi:10.3390/genes8010037

Centromere Stability: The Replication Connection

Program in Molecular & Computational Biology, University of Southern California, Los Angeles, CA 90089-2910, USA
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Academic Editor: Eishi Noguchi
Received: 19 December 2016 / Revised: 10 January 2017 / Accepted: 12 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue DNA Replication Controls)
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Abstract

The fission yeast centromere, which is similar to metazoan centromeres, contains highly repetitive pericentromere sequences that are assembled into heterochromatin. This is required for the recruitment of cohesin and proper chromosome segregation. Surprisingly, the pericentromere replicates early in the S phase. Loss of heterochromatin causes this domain to become very sensitive to replication fork defects, leading to gross chromosome rearrangements. This review examines the interplay between components of DNA replication, heterochromatin assembly, and cohesin dynamics that ensures maintenance of genome stability and proper chromosome segregation. View Full-Text
Keywords: replication; centromere; heterochromatin; fragile site; Swi6; Fork Protection Complex; cohesion replication; centromere; heterochromatin; fragile site; Swi6; Fork Protection Complex; cohesion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Forsburg, S.L.; Shen, K.-F. Centromere Stability: The Replication Connection. Genes 2017, 8, 37.

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